ArticleJournal of clinical laboratory analysis2020
The correlation of long non-coding RNA intersectin 1-2 with disease risk, disease severity, inflammation, and prognosis of acute ischemic stroke.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Long Non-Coding RNAs as Diagnostic Biomarkers for Ischemic Stroke: A Systematic Review and Meta-Analysis.Genes · 2024Pooled it
- Circulating IncRNAs and Their Association With Ischemic Stroke Severity and Prognosis: A Systematic Review and Meta-Analysis.Health science reports · 2026Review
- Juanbi Qianggu Formula inhibits fibroblast-like synovicytes activation via repressing LncRNA ITSN1-2 to promote RIP2 K48 ubiquitination.Chinese medicine · 2025Article
- Differential Expression of Circulating miRNAs and Carfilzomib-Related Cardiovascular Adverse Events in Patients with Multiple Myeloma.International journal of molecular sciences · 2024Article
- Brain alarm by self-extracellular nucleic acids: from neuroinflammation to neurodegeneration.Journal of biomedical science · 2023Review
- lncRNA DHFRL1‑4 knockdown attenuates cerebral ischemia/reperfusion injury by upregulating the levels of angiogenesis‑related genes.International journal of molecular medicine · 2022Article
- Longitudinal variation of circulating Inc-ITSN1-2: A novel biomarker reflecting disease severity, inflammation, recurrence, and death risk in acute ischemic stroke patients.Journal of clinical laboratory analysis · 2022Article
- Blood long non-coding RNA intersectin 1-2 is highly expressed and links with increased Th17 cells, inflammation, multiple organ dysfunction, and mortality risk in sepsis patients.Journal of clinical laboratory analysis · 2022Article
- The Efficacy of Needle-Warming Moxibustion Combined with Hyperbaric Oxygen Therapy for Ischemic Stroke and Its Effect on Neurological Function.Computational and mathematical methods in medicine · 2022Article
- Interleukin-17 and ischaemic stroke.Immunology · 2021Review
- Comprehensive Analysis of Hub Genes Associated With Competing Endogenous RNA Networks in Stroke Using Bioinformatics Analysis.Frontiers in genetics · 2021Article
- MiR-125 Family in Cardiovascular and Cerebrovascular Diseases.Frontiers in cell and developmental biology · 2021Review
- Long Non-Coding RNA-Mediated Competing Endogenous RNA Networks in Ischemic Stroke: Molecular Mechanisms, Therapeutic Implications, and Challenges.Frontiers in pharmacology · 2021Review
- Emerging Role of LncRNAs in Ischemic Stroke-Novel Insights into the Regulation of Inflammation.Journal of inflammation research · 2021Review
- Long noncoding RNA HULC in acute ischemic stroke: Association with disease risk, severity, and recurrence-free survival and relation with IL-6, ICAM1, miR-9, and miR-195.Journal of clinical laboratory analysis · 2020Article
- The correlation of long non-coding RNA intersectin 1-2 with disease risk, disease severity, inflammation, and prognosis of acute ischemic stroke.Journal of clinical laboratory analysis · 2020Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to evaluate the predictive value of long non-coding RNA intersectin 1-2 (lnc-ITSN1-2) for acute ischemic stroke (AIS) risk, and investigate its correlation with disease severity, inflammation, and recurrence-free survival (RFS) in AIS patients.
methodsThree hundred and twenty AIS patients were recruited, and plasma samples were collected within 24 hours after admission. lnc-ITSN1-2 expression form plasma was detected by reverse transcription-quantitative polymerase chain reaction (RT-qPCR). The National Institute of Health Stroke Scale (NIHSS) score was assessed, and RFS was calculated. Meanwhile, 320 controls were enrolled and plasma samples were collected on the enrollment, and lnc-ITSN1-2 expression was detected by RT-qPCR.
resultslnc-ITSN1-2 expression was increased in AIS patients compared to controls (P < .001), and receiver operating characteristic curve revealed its predictive value for AIS risk (area under the curve: 0.804, 95% confidence interval, 0.763-0.845). In AIS patients, lnc-ITSN1-2 expression was positively correlated with NIHSS score (r = 0.464, P < .001). For inflammation, lnc-ITSN1-2 expression was positively correlated with CRP (r = 0.398, P < .001), TNF-α (r = 0.502, P < .001), IL-1β (r = 0.313, P < .001), IL-6 (r = 0.207, P < .001), IL-8 (r = 0.400, P < .001), IL-17 (r = 0.272, P < .001), and IL-22 (r = 0.222, P < .001). In terms of predicted target microRNAs, lnc-ITSN1-2 expression was negatively correlated with microRNA (miR)-107 (r = -0.467, P < .001), miR-125a (r = -0.494, P < .001), and miR-146a (r = -0.126, P = .025). For prognosis, high lnc-ITSN1-2 expression was correlated with worse RFS in AIS patients.
conclusionlnc-ITSN1-2 exerts a good predictive value for AIS risk; meanwhile, its increased expression is correlated with enhanced disease severity, elevated inflammation, and worse RFS in AIS patients.
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Registered trials
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