Trial reportJournal of child psychology and psychiatry, and allied disciplines2020
Trajectories of depression symptom change during and following treatment in adolescents with unipolar major depression.
Trial report in Journal of child psychology and psychiatry, and allied disciplines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Evidence-Base for Psychodynamic Psychotherapy With Children and Adolescents: A Narrative Synthesis.Frontiers in psychology · 2021Pooled it
- Exploring fatigue in clinically depressed adolescents: a secondary analysis of the IMPACT study sample.BMC psychology · 2026Trial
- Heterogeneous trajectories of suicidal ideation and depressive symptoms during an indicated school-based CBT intervention: a group-based trajectory modeling study.BMC psychology · 2026Trial
- Dynamics of depression symptoms in adolescents during three types of psychotherapy and post-treatment follow-up.Journal of child psychology and psychiatry, and allied disciplines · 2025Trial
- Trajectories of parent criticism across treatment for youth self-harm.Journal of child psychology and psychiatry, and allied disciplines · 2025Trial
- Conflicted Anger as a Central Dynamic in Depression in Adolescents-A Double Case Study.International journal of environmental research and public health · 2021Trial
- The Digital Mental Health Study assessed feasibility of large-scale digital sensing for depression and anxiety.npj digital public health · 2026Article
- Annual Research Review: Psychosis in children and adolescents: key updates from the past 2 decades on psychotic disorders, psychotic experiences, and psychosis risk.Journal of child psychology and psychiatry, and allied disciplines · 2025Review
- "You can't really have a relationship with them because they just ask you questions": understanding adolescent dropout - an empirical single case study.Frontiers in psychology · 2024Article
- Development, reach, acceptability and associated clinical changes of a group intervention to improve caregiver-adolescent relationships in the context of adolescent depression.JCPP advances · 2023Article
- Rising early warning signals in affect associated with future changes in depression: a dynamical systems approach.Psychological medicine · 2023Article
- Typical disease courses of patients with unipolar depressive disorder after in-patient treatments-results of a cluster analysis of the INDDEP project.Frontiers in psychiatry · 2023Article
- Predictors, Moderators, and Mediators Associated With Treatment Outcome in Randomized Clinical Trials Among Adolescents With Depression: A Scoping Review.JAMA network open · 2022Article
- Attention Problems and Restlessness as Transdiagnostic Markers of Severity and Treatment Response in Youth with Internalizing Problems.Research on child and adolescent psychopathology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
objectiveTo classify a cohort of depressed adolescents recruited to the UK IMPACT trial, according to trajectories of symptom change. We examined for predictors and compared the data-driven categories of patients with a priori operational definitions of treatment response.
methodSecondary data analysis using growth mixture modelling (GMM). Missing data were imputed. Trajectories of self-reported depressive symptoms were plotted using scores taken at six nominal time points over 86 weeks from randomisation in all 465 patients.
resultsA piecewise GMM categorised patients into two classes with initially similar and subsequently distinct trajectories. Both groups had a significant decline in depressive symptoms over the first 18 weeks. Eighty-four per cent (84.1%, n = 391) of patients were classed as 'continued-improvers' with symptoms reducing over the duration of the study. A further class of 15.9% (n = 74) of patients were termed 'halted-improvers' with higher baseline depression scores, faster early recovery but no further improvement after 18 weeks. Presence of baseline comorbidity somewhat increased membership to the halted-improvers class (OR = 1.40, CI: 1.00-1.96). By end of study, compared with classes, a clinical remission cut-off score (≤27) and a symptom reduction score (≥50%) indexing treatment response misclassified 15% and 31% of cases, respectively.
conclusionsA fast reduction in depressive symptoms in the first few weeks of treatment may not indicate a good prognosis. Halted improvement is only seen after 18 weeks of treatment. Longitudinal modelling may improve the precision of revealing differential responses to treatment. Improvement in depressive symptoms may be somewhat better in the year after treatment than previously considered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.