Evidence map›Paper›PMID 31646885›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

Dual role of cofilin in APP trafficking and amyloid-β clearance.

Tian Liu, Jung-A A Woo, Yan Yan, Patrick LePochat, Mohammed Zaheen Bukhari, David E Kang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Slingshot homolog-1-mediated Nrf2 sequestration tips the balance from neuroprotection to neurodegeneration in Alzheimer's disease.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  3. Article
  4. Review
  5. The Role of ADF/Cofilin in Synaptic Physiology and Alzheimer's Disease.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tian LiuByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
Jung-A A WooByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
Yan YanByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
Patrick LePochatByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
Mohammed Zaheen BukhariByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
David E KangByrd Alzheimer's Institute, University of South Florida (USF) Health, Tampa, Florida, USA.
University of South Florida · USUSF Health Byrd Alzheimer's Institute · USJames A. Haley Veterans' Hospital · US

Funding

Role of the Slingshot-1 pathway in APP and Tau pathogenesisRF1AG053060 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI KANG, DAVID E · 2017 to 2017
$1.9M
BLRD VA I01 BX002478NIA NIH HHS RF1 AG053060
6 · The paper itself

Abstract

The accumulation of amyloid-β (Aβ) plays a pivotal early event in the pathogenesis of Alzheimer's disease (AD). In the brain, neurons produce Aβ by the proteolytic processing of amyloid precursor protein (APP) through the endocytic pathway, whereas microglia mediate Aβ clearance also

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein SecretasesAnimalsCHO CellsCricetinaeCricetulusGene Expression RegulationGene Knockdown TechniquesMiceMice, Inbred StrainsMice, TransgenicMicrogliaAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAmyloid Precursor Protein Secretasesactin dynamicsamyloid precursor proteinAβ microgliaendocytosis

Identifiers

PMID31646885
PMCPMC6894083
OpenAlexW2981782790

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.