ArticleEpilepsia2020
Realistic driving simulation during generalized epileptiform discharges to identify electroencephalographic features related to motor vehicle safety: Feasibility and pilot study.
Article in Epilepsia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Focal seizures during simulated driving: A pilot study.Epilepsia · 2026Article
- Digital Response Test in Epilepsy assesses interictal epileptiform discharge effects in real time.Epilepsia · 2026Article
- Distinct spike-and-wave EEG profiles reveal susceptibility to fleeting/almost loss of consciousness (so-called blips) in generalized epilepsy.Epilepsia · 2025Article
- Simulated driving behavior over the adult age span.Frontiers in aging neuroscience · 2025Article
- Electroencephalographic compatibility with fitness to drive: A nationwide survey among Swiss neurologists.Epilepsia open · 2024Article
- Predictive Power of Interictal Epileptiform Discharges in Fitness-to-Drive Evaluation.Neurology · 2023Article
- The seizure severity score: a quantitative tool for comparing seizures and their response to therapy.Journal of neural engineering · 2023Article
- A machine-learning approach for predicting impaired consciousness in absence epilepsy.Annals of clinical and translational neurology · 2022Article
- Reliability of patient self-report of cognition, awareness, and consciousness during seizures.Annals of clinical and translational neurology · 2022Article
- Simulated driving in the epilepsy monitoring unit: Effects of seizure type, consciousness, and motor impairment.Epilepsia · 2022Article
- Spatiotemporal dynamics between interictal epileptiform discharges and ripples during associative memory processing.Brain : a journal of neurology · 2021Article
- Timelined multimodal recording of EEG and driving performance using a driving simulator system during a focal impaired awareness seizure.Epilepsy & behavior reports · 2020Article
Corrections and comments
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Authors and funding
19 authors at 2 institutions in 4 countries.
Funding
Abstract
objectiveGeneralized epileptiform discharges (GEDs) can occur during seizures or without obvious clinical accompaniment. Motor vehicle driving risk during apparently subclinical GEDs is uncertain. Our goals were to develop a feasible, realistic test to evaluate driving safety during GEDs, and to begin evaluating electroencephalographic (EEG) features in relation to driving safety.
methodsSubjects were aged ≥15 years with generalized epilepsy, GEDs on EEG, and no clinical seizures. Using a high-fidelity driving simulator (miniSim) with simultaneous EEG, a red oval visual stimulus was presented every 5 minutes for baseline testing, and with each GED. Participants were instructed to pull over as quickly and safely as possible with each stimulus. We analyzed driving and EEG signals during GEDs.
resultsNine subjects were tested, and five experienced 88 GEDs total with mean duration 2.31 ± 1.89 (SD) seconds. Of these five subjects, three responded appropriately to all stimuli, one failed to respond to 75% of stimuli, and one stopped driving immediately during GEDs. GEDs with no response to stimuli were significantly longer than those with appropriate responses (8.47 ± 3.10 vs 1.85 ± 0.69 seconds, P < .001). Reaction times to stimuli during GEDs were significantly correlated with GED duration (r = 0.30, P = .04). In addition, EEG amplitude was greater for GEDs with no response to stimuli than GEDs with responses, both for overall root mean square voltage amplitude (66.14 μV vs 52.99 μV, P = .02) and for fractional power changes in the frequency range of waves (P < .05) and spikes (P < .001). SIGNIFICANCE: High-fidelity driving simulation is feasible for investigating driving behavior during GEDs. GEDs with longer duration and greater EEG amplitude showed more driving impairment. Future work with a large sample size may ultimately enable classification of GED EEG features to predict individual driving risk.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.