ArticleClinical oral investigations2020
Xenogeneic bone filling materials modulate mesenchymal stem cell recruitment: role of the Complement C5a.
Article in Clinical oral investigations, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Effects of photobiomodulation on human dental pulp stem cells treated with a bone xenograft: An in vitro study.Lasers in medical science · 2026Article
- Collagen Formulation in Xenogeneic Bone Substitutes Influences Cellular Responses in Periodontal Regeneration: An In Vitro Study.Biomimetics (Basel, Switzerland) · 2025Article
- Fibrinogen-Induced Regeneration Sealing Technique (F.I.R.S.T.): A Retrospective Clinical Study on 105 Implants with a 3-7-Year Follow-Up.Journal of clinical medicine · 2024Article
- Bone Regeneration with Dental Pulp Stem Cells in an Experimental Model.Journal of personalized medicine · 2024Article
- The Added Value of a Collagenated Thermosensitive Bone Substitute as a Scaffold for Bone Regeneration.Materials (Basel, Switzerland) · 2024Article
- Osteogenic Potential of a Polyethylene Glycol Hydrogel Functionalized with Poly-Lysine Dendrigrafts (DGL) for Bone Regeneration.Materials (Basel, Switzerland) · 2023Article
- A Narrative Review on the Effectiveness of Bone Regeneration Procedures with OsteoBiolJournal of functional biomaterials · 2022Review
- Complement activation links inflammation to dental tissue regeneration.Clinical oral investigations · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWhen bone filling materials are applied onto the periodontal tissues in vivo, they interact with the injured periodontal ligament (PDL) tissue and modulate its activity. This may lead to mesenchymal stem cells (MSCs) recruitment from bone marrow and initiate bone regeneration. Our hypothesis is that the filling materials affect PDL cells and MSCs functional activities by modulating PDL C5a secretion and subsequent MSCs proliferation and recruitment. MATERIALS AND
methodsMaterials' extracts were prepared from 3 bone-grafting materials: Gen-Os
resultsMSCs proliferation significantly increased with Gen-Os
conclusionsInjured PDL cells secrete C5a leading MSCs proliferation and recruitment to the PDL injured cells. Gen-Os CLINICAL RELEVANCE: Within the limits of this study in vitro, Gen-Os
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.