ReviewCardiovascular endocrinology & metabolism2019
Vascular disease in the lower limb in type 1 diabetes.
Review in Cardiovascular endocrinology & metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 22 citations in OpenAlex.
- Ultrasound Evaluation of Lower-Limb Arterial Morphology and Hemodynamics in Type 2 Diabetes Mellitus Versus Non-Diabetic Controls: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- The Effect of Revascularization on Lower Limb Circulation Parameters in Symptomatic Peripheral Arterial Disease.Journal of clinical medicine · 2024Article
- A Tryptophan Metabolite of the Microbiota Improves Neovascularization in Diabetic Limb Ischemia.Frontiers in cardiovascular medicine · 2022Article
- Risk Factors of Peripheral Vascular Disease in Diabetes Mellitus in Abbottabad, Pakistan: A Cross-Sectional Study.Cureus · 2021Article
- Popliteal Entrapment Syndrome as a Cause of Chronic Lower Extremity Pain in a 16-Year Old.Cureus · 2021Article
- Introduction to ion channels and calcium signaling in the microcirculation.Current topics in membranes · 2020Review
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
This review considers peripheral arterial disease (PAD) in the diabetic ischaemic lower limb including both macrovascular and microvascular aspects. The presentation of PAD is probably not significantly different in type 1 compared with type 2 diabetes. PAD in diabetic patients is diffuse and located distally being most severe in the crural and also the foot arteries. It is associated with arterial calcification and occlusion of the arteries rather than stenosis. Compared with the nondiabetic patient, PAD develops at a younger age, and women are equally affected as men. It is not known whether the presentation of ischaemic lower limb disease in diabetes can be explained by one disease, namely, atherosclerosis, which has particular features peculiar to diabetes such as distal arterial involvement, or by the occurrence of two separate diseases: first, classical atherosclerosis and, second, a diabetic macroangiopathy, a term for nonatherosclerotic arterial disease in diabetes that is characterized by medial arterial calcification. Furthermore, there is controversy with regard to the significance of structural changes in the microcirculation of the diabetic foot.
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