ArticleCardiovascular endocrinology & metabolism2018
Serum leptin in male hypothyroid prediabetic patients: Association with cardiovascular risk.
Article in Cardiovascular endocrinology & metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.
- Circulating leptin levels in thyroid dysfunction: a systematic review and meta-analysis.BMC endocrine disorders · 2025Pooled it
- Review
- Renal function changes in patients with subclinical hyperthyroidism: a novel postulated mechanism.Endocrine · 2023Article
- Alterations of Serum Leptin Levels in Patients with Autoimmune Thyroid Disorders.Medical journal of the Islamic Republic of Iran · 2021Article
- Type 2 Diabetes Mellitus non-surgical remission: A possible mission.Journal of clinical & translational endocrinology · 2019Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHyperliptenemia is a risk factor for coronary heart disease (CHD). Hypothyroidism and prediabetes confer an increased cardiovascular risk. Few studies have addressed the role of leptin in hypothyroid prediabetic patients and its effect on CHD risk factors.
objectiveThe aim of this study was to detect serum levels of leptin in hypothyroid prediabetic patients and their relationship with risk factors for CHD. PATIENTS AND
methodsThe study included three groups; group A included 120 hypothyroid male patients with normal glucose tolerance, group B included 120 hypothyroid male patients with prediabetes, and group C included 120 healthy individuals matched for age and sex as a control group. All groups were subjected to assessment of history, clinical examination, and laboratory investigations including fasting and 2 h postprandial blood glucose, serum total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), free T3, free T4, thyroid-stimulating hormone, and fasting serum leptin.
resultsSerum leptin was significantly higher in groups A and B compared with group C (
conclusionHypothyroidism is associated with high serum leptin independent of prediabetic state. Serum leptin in hypothyroid prediabetic patients showed a direct relationship with some primary markers of metabolic syndrome; thus, leptin may predict the development of CHD in those patients.
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