ArticleBiomedical optics express2019
Concurrent fluorescence and volumetric optoacoustic tomography of nanoagent perfusion and bio-distribution in solid tumors.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Evaluations of Oxygenation and Vascular Perfusion in Pre-Clinical Models of Cancer and Wound Healing Using OS-DCE OAI.Journal of visualized experiments : JoVE · 2026Article
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's diseasebioRxiv : the preprint server for biology · 2023Article
- Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain.Photoacoustics · 2023Article
- Simultaneous Functional Magnetic Resonance and Optoacoustic Imaging of Brain-Wide Sensory Responses in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Three-dimensional wide-field fluorescence microscopy for transcranial mapping of cortical microcirculation.Nature communications · 2022Article
- Multifunctional croconaine nanoparticles for efficient optoacoustic imaging of deep tumors and photothermal therapy.Nanophotonics (Berlin, Germany) · 2022Article
- Hybrid magnetic resonance and optoacoustic tomography (MROT) for preclinical neuroimaging.Light, science & applications · 2022Article
- Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography.European journal of nuclear medicine and molecular imaging · 2022Article
- Inhibitory of active dual cancer targeting 5-Fluorouracil nanoparticles on liver cancerFrontiers in oncology · 2022Article
- Indocyanine green dye based bimodal contrast agent tested by photoacoustic/fluorescence tomography setup.Biomedical optics express · 2021Article
- Development of Multispectral Optoacoustic Tomography as a Clinically Translatable Modality for Cancer Imaging.Radiology. Imaging cancer · 2020Review
- Skin Barriers in Dermal Drug Delivery: Which Barriers Have to Be Overcome and How Can We Measure Them?Pharmaceutics · 2020Review
- Multifocal structured illumination optoacoustic microscopy.Light, science & applications · 2020Article
- Recent progress in optical probing and manipulation of tissue: introduction.Biomedical optics express · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intravenously administered liposomes and other nano-sized particles are known to passively accumulate in solid tumors via the enhanced permeability and retention (EPR) effect, which is extensively explored toward the improvement of diagnosis and drug delivery in oncology. Agent extravasation into tumors is often hampered by the mononuclear phagocytic and renal systems, which sequester and/or eliminate most of the nanoparticles from the body. Dynamic imaging of the tumor microcirculation and bolus perfusion can thus facilitate optimization of the nanoparticle delivery. When it comes to non-invasive visualization of rapid biological dynamics in whole tumors, the currently available pre-clinical imaging modalities are commonly limited by shallow penetration, lack of suitable contrast or otherwise insufficient spatial or temporal resolution. Herein, we demonstrate the unique capabilities of a combined epi-fluorescence and optoacoustic tomography (FLOT) system for characterizing contrast agent dynamics in orthotopic breast tumors in mice. A liposomal indocyanine green (Lipo-ICG) preparation was administered intravenously with the time-lapse data continuously acquired during and after the injection procedure. In addition to the highly sensitive detection of the fluorescence agent by the epi-fluorescence modality, the volumetric multi-spectral optoacoustic tomography readings further enabled resolving deep-seated vascular structures with high spatial resolution and hence provided accurate readings of the dynamic bio-distribution of nanoparticles in the entire tumor in 3D. The synergetic combination of the two modalities can become a powerful tool in cancer research and potentially aid the diagnosis, staging and treatment guidance of certain types of cancer in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.