ArticleBiomedical optics express2019
Aberration-free multi-plane imaging of neural activity from the mammalian brain using a fast-switching liquid crystal spatial light modulator.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Spatial light modulation for interferometric scattering microscopy.Journal of microscopy · 2025Article
- Review
- Axial motion estimation and correction for simultaneous multi-plane two-photon calcium imaging.Biomedical optics express · 2022Article
- Fast optical recording of neuronal activity by three-dimensional custom-access serial holography.Nature methods · 2022Article
- Structure and function of axo-axonic inhibition.eLife · 2021Article
- Laminar distribution and arbor density of two functional classes of thalamic inputs to primary visual cortex.Cell reports · 2021Article
- Precompensation of 3D field distortions in remote focus two-photon microscopy.Biomedical optics express · 2021Article
- Whole brain functional recordings at cellular resolution in zebrafish larvae with 3D scanning multiphoton microscopy.Scientific reports · 2021Article
- Adaptive optics enables aberration-free single-objective remote focusing for two-photon fluorescence microscopy.Biomedical optics express · 2021Article
- Pupil plane actuated remote focusing for rapid focal depth control.Optics express · 2020Article
- Wide. Fast. Deep: Recent Advances in Multiphoton Microscopy ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Review
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We report a novel two-photon fluorescence microscope based on a fast-switching liquid crystal spatial light modulator and a pair of galvo-resonant scanners for large-scale recording of neural activity from the mammalian brain. The spatial light modulator is used to achieve fast switching between different imaging planes in multi-plane imaging and correct for intrinsic optical aberrations associated with this imaging scheme. The utilized imaging technique is capable of monitoring the neural activity from large populations of neurons with known coordinates spread across different layers of the neocortex in awake and behaving mice, regardless of the fluorescent labeling strategy. During each imaging session, all visual stimulus driven somatic activity could be recorded in the same behavior state. We observed heterogeneous response to different types of visual stimuli from
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Registered trials
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