ArticleBiomedical optics express2019
Method to improve the depth sensitivity of diffuse reflectance measurements to absorption changes in optically turbid medium.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Functional dual-slope frequency-domain near-infrared spectroscopy data interpreted with two- and three-layer models.Biophotonics discovery · 2026Article
- Article
- Influence of Uncertainties in Optode Positions on Self-Calibrating or Dual-Slope Diffuse Optical Measurements.Photonics · 2025Article
- Spatial Sensitivity to Absorption Changes for Various Near-Infrared Spectroscopy Methods: A Compendium Review.Journal of innovative optical health sciences · 2024Article
- Depth-selective method for time-domain diffuse reflectance measurements: validation study of the dual subtraction technique.Biomedical optics express · 2023Article
- Novel data types for frequency-domain diffuse optical spectroscopy and imaging of tissues: characterization of sensitivity and contrast-to-noise ratio for absorption perturbations.Biomedical optics express · 2023Article
- Dual-slope imaging of cerebral hemodynamics with frequency-domain near-infrared spectroscopy.Neurophotonics · 2023Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
- Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response.Biomedical optics express · 2022Article
- Noninvasive Optical Measurements of Dynamic Cerebral Autoregulation by Inducing Oscillatory Cerebral Hemodynamics.Frontiers in neurology · 2021Article
- Direct assessment of extracerebral signal contamination on optical measurements of cerebral blood flow, oxygenation, and metabolism.Neurophotonics · 2020Article
- Design of a source-detector array for dual-slope diffuse optical imaging.The Review of scientific instruments · 2020Article
- Dual-slope imaging in highly scattering media with frequency-domain near-infrared spectroscopy.Optics letters · 2020Article
- Depth-selective data analysis for time-domain fNIRS: moments vs. time windows.Biomedical optics express · 2020Article
- Frequency-Domain Techniques for Cerebral and Functional Near-Infrared Spectroscopy.Frontiers in neuroscience · 2020Review
- Transformational change in the field of diffuse optics: From going bananas to going nuts.Journal of innovative optical health sciences · 2020Article
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Authors and funding
2 authors.
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No grant is acknowledged in the PubMed record.
Abstract
We have studied the spatial distributions of the sensitivity of time-resolved near-infrared diffuse reflectance measurement. Sensitivity factors representing a change of parameters of a measured optical signal induced by absorption perturbation in a certain voxel of the medium were simulated using the diffusion equation solution. The parameters were statistical moments of measured distributions of time of flight of photons (DTOFs) i.e., the total number of photons, mean time of flight and variance. The distributions of the sensitivity of statistical moments of DTOFs to a change in absorption were generated for various source-detector separations and various optical properties of the medium. Furthermore, differential sensitivity distributions for two different source-detector separations were calculated. A measurement geometry, in which two detection spots, separated by 5 mm, in combination with two sources was proposed. For this setup differences between the signals obtained for both detectors were calculated independently for both sources and afterward summed up for both source positions. Obtained differences in moments of DTOFs assessed at two source-detector separations and summed up for different positioning of the sources allowed to shape up the sensitivity profiles. Calculated sensitivity profiles show that positive sensitivities of the mean time of flight of photons and variance of the DTOF can be obtained. These positive sensitivity areas are located just between both detection spots and cover the compartment located deeply in the medium. The sensitivity in superficial compartments of the medium is negative and much smaller in amplitude. The proposed technique can be used for improved discrimination of optical signals related to the intracerebral change in absorption which remains a serious obstacle in the application of the NIRS technique in the assessment of brain oxygenation or perfusion.
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