ArticleBiomedical optics express2019
Effective demethylation of melanoma cells using terahertz radiation.
Article in Biomedical optics express, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Effect of terahertz radiation on cells and cellular structures.Frontiers of optoelectronics · 2025Review
- Terahertz Irradiation Promotes Angiogenesis in vitro by Enhancing Permeability of the Voltage-Gated Calcium Channel.PloS one · 2025Article
- Transcriptomic Analysis of Blood Collagen-Induced Arthritis Mice Exposed to 0.1 THz Reveals Inhibition of Genes and Pathways Involved in Rheumatoid Arthritis.International journal of molecular sciences · 2024Article
- The Transcriptomic Response of Cells of the Thermophilic BacteriumInternational journal of molecular sciences · 2024Article
- Terahertz Radiation Modulates Neuronal Morphology and Dynamics Properties.Brain sciences · 2024Review
- TerahertzAPL bioengineering · 2024Article
- The biological effects of terahertz wave radiation-induced injury on neural stem cells.iScience · 2023Article
- Investigating the function and design of molecular materials through terahertz vibrational spectroscopy.Nature reviews. Chemistry · 2023Review
- High Frequency Electromagnetic Radiation Stimulates Neuronal Growth and Hippocampal Synaptic Transmission.Brain sciences · 2023Article
- Epigenetic modification of gene expression in cancer cells by terahertz demethylation.Scientific reports · 2023Article
- Skin Cancer Pathobiology at a Glance: A Focus on Imaging Techniques and Their Potential for Improved Diagnosis and Surveillance in Clinical Cohorts.International journal of molecular sciences · 2023Review
- The laws and effects of terahertz wave interactions with neurons.Frontiers in bioengineering and biotechnology · 2023Article
- Measurement of tissue optical properties in a wide spectral range: a review [Invited].Biomedical optics express · 2023Review
- Specific Features of the Proteomic Response of Thermophilic BacteriumInternational journal of molecular sciences · 2022Article
- Effects of high intensity non-ionizing terahertz radiation on human skin fibroblasts.Biomedical optics express · 2021Article
- Cellular effects of terahertz waves.Journal of biomedical optics · 2021Review
- Machine Learning Techniques for THz Imaging and Time-Domain Spectroscopy.Sensors (Basel, Switzerland) · 2021Review
- Terahertz radiation and the skin: a review.Journal of biomedical optics · 2021Review
- Molecular identification of Candida isolates by Real-time PCR-high-resolution melting analysis and investigation of the genetic diversity of Candida species.Journal of clinical laboratory analysis · 2020Article
- Transformation of terahertz vibrational modes of cytosine under hydration.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Terahertz (THz) demethylation is a photomedical technique applied to dissociate methyl-DNA bonds and reduce global DNA methylation using resonant THz radiation. We evaluated the performance of THz demethylation and investigated the DNA damage caused by THz irradiation. The demethylation rate in M-293T DNA increased linearly with the irradiation power up to 48%. The degree of demethylation increased with exposure to THz radiation, saturating after 10 min. Although THz demethylation occurred globally, most of the demethylation occurred within the partial genes in the CpG islands. Subsequently, we performed THz demethylation of melanoma cells. The degree of methylation in the melanoma cell pellets decreased by approximately 10-15%, inducing ∼5-8 abasic sites per 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.