ReviewBone research2019
Evolving concepts in bone infection: redefining "biofilm", "acute vs. chronic osteomyelitis", "the immune proteome" and "local antibiotic therapy".
Open access · goldAbstract readReview
In one paragraph
Review in Bone research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 283 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
283citing papers in PubMed, 2 pooled it
49.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
283 citing papers in PubMed, 2 syntheses or guidelines pooled it, 505 citations in OpenAlex.
- Lower limb post-traumatic osteomyelitis: a systematic review of clinical outcomes.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Pooled it
- Current therapeutic interventions combating biofilm-related infections in orthopaedics : a systematic review of in vivo animal studies.Bone & joint research · 2022Pooled it
- Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.Bioactive materials · 2027Review
- Nomogram for predicting inadequate treatment response in vertebral osteomyelitis.Annals of medicine · 2026Article
- A multiscale pathoanatomical atlas guides the design of functionally graded, anatomically intelligent implants for chronic osteomyelitis.Bioactive materials · 2026Article
- Mild photothermal-responsive hydrogel with HBioactive materials · 2026Article
- Osteomyelitis: Epidemiology, Classification, Pathophysiology, Clinical Features, Diagnosis, and Management.MedComm · 2026Review
- Clinical characteristics and risk factors of recurrence for Pseudomonas aeruginosa-associated fracture-related infection following surgical treatment : a 12-year retrospective cohort study.Bone & joint open · 2026Article
- Biofilm Dynamics and Antimicrobial Resistance in Rabbit Odontogenic Infections: A One Health Perspective.Pathogens (Basel, Switzerland) · 2026Review
- Current and emerging biomaterials for targeted drug delivery in osteomyelitis management.Discover nano · 2026Review
- Bioelectric warfare on bone infection: The role of piezoelectric biomaterials in osteomyelitis management.Fundamental research · 2026Review
- MRSA-dominant colonization and synergistic pathogenicity withJournal of orthopaedic translation · 2026Article
- Bacterial growth under confinement requires transcriptional adaptation to resist turgor pressure build-up.Nature communications · 2026Article
- 3D-Printed Vancomycin- and Gentamicin-Loaded Bone Grafts for Osteomyelitis Treatment: Drug Release and Antibacterial Efficacy.ACS omega · 2026Article
- Defect-Mediated Sonodynamic Catalysis on Calcium-Deficient Hydroxyapatite Nanoparticles Coordinating Bacterial Elimination and Bone Regeneration against Osteomyelitis.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Proximal Humerus Osteomyelitis After Influenza Vaccination Administration.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Article
- Amine-linked heteroporous covalent organic framework for synergistic anti-infective therapy of post-traumatic osteomyelitis.Nature communications · 2026Article
- Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review).International journal of molecular medicine · 2026Review
- Clinical Characteristics of Patients with Long-Bone Fracture Nonunion and Delayed Union and Factors Associated with Infection: A Retrospective Single-Center Cohort Study.Journal of clinical medicine · 2026Article
- Metformin as a Metabolic Reprogramming Interface in Host-Pathogen and Bone Microenvironment Crosstalk: A Dual-Target Strategy Against Antimicrobial Resistance and Osteoporotic Bone Loss.Antibiotics (Basel, Switzerland) · 2026Review
223 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 3 institutions in 2 countries.
Elysia A Masters1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.ORCID 0000-0002-9981-624X
Ryan P Trombetta1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Karen L de Mesy Bentley1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Brendan F Boyce1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Ann Lindley Gill5Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY USA.
Steven R Gill5Department of Microbiology & Immunology, University of Rochester Medical Center, Rochester, NY USA.
Kohei Nishitani1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Masahiro Ishikawa1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Yugo Morita1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Hiromu Ito6Department of Orthopaedic Surgery, Kyoto University, Kyoto, Japan.
Sheila N Bello-Irizarry1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Mark Ninomiya1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
James D Brodell1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Charles C Lee1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Stephanie P Hao1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Irvin Oh1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Chao Xie1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
Hani A Awad1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
John L Daiss1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.
John R Owen7Department of Orthopaedic Surgery, Virginia Commonwealth University Medical Center, Richmond, VA USA.
Stephen L Kates7Department of Orthopaedic Surgery, Virginia Commonwealth University Medical Center, Richmond, VA USA.
Edward M Schwarz1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.ORCID 0000-0002-4854-9698
Gowrishankar Muthukrishnan1Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY USA.ORCID 0000-0001-7521-6154
University of Rochester Medical Center · USKyoto University · JPVirginia Commonwealth University · US
Funding
Project 2: Defining the Protective vs. Susceptible Immune Proteome of S. aureus OsteomyelitisP50AR072000 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2017 to 2026
$13.6MStudies on the fate of the OsteoclastR01AR043510 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR SAN ANT · PI BOYCE, BRENDAN F · 1995 to 2025
$8.4MRochester Resource-Based Center for Bone, Muscle and Orthopaedic Research (ROCSTARR) (Overall Application)P30AR069655 · NIAMS · UNIVERSITY OF ROCHESTER · PI Edward M. Schwarz · 2016 to 2026
$7.8MTraining in Orthopaedic Researchhttps://apps.era.nih.gov/grantfolder/viewInternalGF.era?applId=8841318&folderId=90T32AR053459 · NIAMS · UNIVERSITY OF ROCHESTER · PI ZUSCIK, MICHAEL J · 2006 to 2017
$3.4MThe University of Rochester Core Center for Musculoskeletal Biology and MedicineP30AR061307 · NIAMS · UNIVERSITY OF ROCHESTER · PI SCHWARZ, EDWARD M. · 2011 to 2015
$3.0MStudies of TRAF3 in age-related low-level chronic inflammation and osteoporosisR01AG049994 · NIA · UNIVERSITY OF ROCHESTER · PI BOYCE, BRENDAN F, YAO, ZHENQIANG · 2016 to 2020
$1.6MDiagnosis of early Staphylococcus aureus infections using circulating plasmablastsR21AI119646 · NIAID · UNIVERSITY OF ROCHESTER · PI DAISS, JOHN LINFORTH · 2016 to 2017
$422kPathogen-specific and Prognosis of S. aureus infection in Orthopaedic SurgeryR21AR074571 · NIAMS · YALE UNIVERSITY · PI OH, IRVIN · 2018 to 2019
$376kS. aureus Colonization of the Osteocytic-Canalicular Network in Diabetic Foot UlcersR21AR073321 · NIAMS · UNIVERSITY OF ROCHESTER · PI OH, IRVIN · 2018 to 2019
$373kNIAID NIH HHS R21 AI119646NIAMS NIH HHS P30 AR061307NIAMS NIH HHS P30 AR069655NIAMS NIH HHS P50 AR072000NIAMS NIH HHS R01 AR043510NIAMS NIH HHS R21 AR073321NIAMS NIH HHS R21 AR074571NIAMS NIH HHS T32 AR053459NIA NIH HHS R01 AG049994
Abstract
Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high.
Indexed as
BoneDiseases
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.