ReviewLight, science & applications2019
Single-photon avalanche diode imagers in biophotonics: review and outlook.
Review in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 121 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
121 citing papers in PubMed.
- Superconducting nanowire single-photon detectors for enhanced biomedical imaging.Journal of biomedical optics · 2026Article
- Neuromorphic Optical Tracking and Imaging of Randomly Moving Targets Through Dynamic Dense Scattering Media.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A single-chip, dual-gain color-NIR camera for fluorescence-guided lung and breast cancer surgery.Light, science & applications · 2026Article
- Nanophotonic Design of Germanium-Silicon Single-Photon Detectors for Integrated Quantum Photonic Circuits.Nanophotonics (Berlin, Germany) · 2026Article
- An FPGA-Based Event-Timing Front-End for Time-Resolved Sensing with Dual-Mode Experimental Characterization.Sensors (Basel, Switzerland) · 2026Article
- Interrogating nanopores with light: optipore sensing for single molecule analyses.Journal of nanobiotechnology · 2026Review
- Two-dimensional fluorescence spectroscopy with entangled photons and time- and frequency-resolved two-photon coincidence detection.Science advances · 2026Article
- Reduction in Dark Current in Photodiodes: A Review.Micromachines · 2026Review
- Evaluation of a time-resolved singlet oxygen detection system for in vivo photodynamic therapy.Biomedical optics express · 2026Article
- An ultrafast plenoptic-camera system for high-resolution 3D particle tracking in unsegmented scintillators.Nature communications · 2026Article
- A review of SPAD array chip design for direct time-of-flight LiDAR.Discover nano · 2026Review
- Thermal detection of single photons using Dirac fermions.Nature communications · 2026Article
- Low breakdown field and high ionization index in ReSeNature communications · 2026Article
- Large-array sub-millimeter precision coherent flash three-dimensional imaging.Nature communications · 2026Article
- Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Single-Photon Single-Particle Tracking.bioRxiv : the preprint server for biology · 2025Article
- Wide-field fluorescence lifetime imaging of single molecules with a gated single-photon camera.Light, science & applications · 2025Article
- High-speed fluorescence lifetime imaging microscopy: techniques, applications, and prospects.Biophotonics discovery · 2025Review
- Applications of Fluorescence Technology for Rapid Identification of Marine Plastic Pollution.Polymers · 2025Review
- Spatiotemporal Exciton Tracking with a SPAD Camera.ACS photonics · 2025Article
61 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single-photon avalanche diode (SPAD) arrays are solid-state detectors that offer imaging capabilities at the level of individual photons, with unparalleled photon counting and time-resolved performance. This fascinating technology has progressed at a very fast pace in the past 15 years, since its inception in standard CMOS technology in 2003. A host of architectures have been investigated, ranging from simpler implementations, based solely on off-chip data processing, to progressively "smarter" sensors including on-chip, or even pixel level, time-stamping and processing capabilities. As the technology has matured, a range of biophotonics applications have been explored, including (endoscopic) FLIM, (multibeam multiphoton) FLIM-FRET, SPIM-FCS, super-resolution microscopy, time-resolved Raman spectroscopy, NIROT and PET. We will review some representative sensors and their corresponding applications, including the most relevant challenges faced by chip designers and end-users. Finally, we will provide an outlook on the future of this fascinating technology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.