Evidence map›Paper›PMID 31645921›Full record

ArticleLight, science & applications2019

Colour compound lenses for a portable fluorescence microscope.

Bo Dai, Ziao Jiao, Lulu Zheng, Hunter Bachman, Yongfeng Fu, Xinjun Wan, Yule Zhang, Yu Huang, Xiaodian Han, Chenglong Zhao and 3 more

Open access · goldAbstract read
In one paragraph

Article in Light, science & applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 95 citations in OpenAlex.

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  10. Light People: Academician Songlin Zhuang.Light, science & applications · 2022
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  19. Proceedings of the 7th ACM International Conference on Nanoscale Computing and Communication : Virtual Conference, September 23-25, 2020 : NanoCom 2020. ACM International Conference on Nanoscale Computing and Communication (7th : 2020 :... · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Bo Dai *1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Ziao Jiao *1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Lulu Zheng *1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Hunter Bachman2Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27709 USA.
Yongfeng Fu3Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Fudan University, 200032 Shanghai, China.
Xinjun Wan1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Yule Zhang1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Yu Huang1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Xiaodian Han4Department of Laboratory Medicine, Shanghai Cancer Center, Fudan University, 200032 Shanghai, China.
Chenglong Zhao5Department of Physics, University of Dayton, Dayton, OH 45469 USA.
Tony Jun Huang2Department of Mechanical Engineering and Materials Science, Duke University, Durham, NC 27709 USA.ORCID 0000-0003-1205-3313
Songlin Zhuang1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
Dawei Zhang1Engineering Research Center of Optical Instrument and System, the Ministry of Education, Shanghai Key Laboratory of Modern Optical System, University of Shanghai for Science and Technology, 200093 Shanghai, China.
University of Shanghai for Science and Technology · CNDuke University · USFudan University Shanghai Cancer Center · CNShanghai Medical College of Fudan University · CNUniversity of Dayton · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this article, we demonstrated a handheld smartphone fluorescence microscope (HSFM) that integrates dual-functional polymer lenses with a smartphone. The HSFM consists of a smartphone, a field-portable illumination source, and a dual-functional polymer lens that performs both optical imaging and filtering. Therefore, compared with the existing smartphone fluorescence microscope, the HSFM does not need any additional optical filters. Although fluorescence imaging has traditionally played an indispensable role in biomedical and clinical applications due to its high specificity and sensitivity for detecting cells, proteins, DNAs/RNAs, etc., the bulky elements of conventional fluorescence microscopes make them inconvenient for use in point-of-care diagnosis. The HSFM demonstrated in this article solves this problem by providing a multifunctional, miniature, small-form-factor fluorescence module. This multifunctional fluorescence module can be seamlessly attached to any smartphone camera for both bright-field and fluorescence imaging at cellular-scale resolutions without the use of additional bulky lenses/filters; in fact, the HSFM achieves magnification and light filtration using a single lens. Cell and tissue observation, cell counting, plasmid transfection evaluation, and superoxide production analysis were performed using this device. Notably, this lens system has the unique capability of functioning with numerous smartphones, irrespective of the smartphone model and the camera technology housed within each device. As such, this HSFM has the potential to pave the way for real-time point-of-care diagnosis and opens up countless possibilities for personalized medicine.

Indexed as

Optical materials and structuresOptics and photonics

Identifiers

PMID31645921
PMCPMC6804733
OpenAlexW2969242542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.