Evidence map›Paper›PMID 31645763›Full record

ArticleNature2019

Evolution of the new head by gradual acquisition of neural crest regulatory circuits.

Megan L Martik, Shashank Gandhi, Benjamin R Uy, J Andrew Gillis, Stephen A Green, Marcos Simoes-Costa, Marianne E Bronner

Open access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 96 citations in OpenAlex.

  1. Article
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  5. Review
  6. Regulatory logic underlying neural crest contributions to the head versus the heart.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Review
  8. Article
  9. Ectomesenchymal identity emerges via relief ofbioRxiv : the preprint server for biology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Megan L MartikDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Shashank GandhiDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Benjamin R UyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
J Andrew GillisDepartment of Zoology, University of Cambridge, Cambridge, UK.
Stephen A GreenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Marcos Simoes-CostaDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA.
Marianne E BronnerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA. mbronner@caltech.edu.
California Institute of Technology · USCornell University · USUniversity of Cambridge · GB

Funding

Progressive acquisition of novel neural crest derivatives along the neural axis during vertebrate evolutionR35NS111564 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI Marianne Bronner · 2019 to 2026
$5.0M
Gene Regulatory Network Controlling Premigratory Cranial vs Trunk Neural CrestR01DE024157 · NIDCR · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2025
$4.0M
Regulatory Changes Mediating Emergence of Novel Neural Crest TraitsR01NS086907 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2014 to 2018
$1.8M
Progressive evolution and expansion of the vertebrate neural crest along the body axisR01NS108500 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI BRONNER, MARIANNE · 2019 to 2019
$360k
NIDCR NIH HHS R01 DE024157NINDS NIH HHS R01 NS086907NINDS NIH HHS R01 NS108500NINDS NIH HHS R35 NS111564
6 · The paper itself

Abstract

The neural crest, an embryonic stem-cell population, is a vertebrate innovation that has been proposed to be a key component of the 'new head', which imbued vertebrates with predatory behaviour

Indexed as

Biological EvolutionBody PatterningHeadNeural CrestAnimalsGene Expression Regulation, DevelopmentalLampreysSkullZebrafish

Identifiers

PMID31645763
PMCPMC6858584
OpenAlexW2981473957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.