ArticleNature2019
Alcohol metabolism contributes to brain histone acetylation.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed, 1 pooled it
9.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
167 citing papers in PubMed, 1 synthesis or guideline pooled it, 271 citations in OpenAlex.
- Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals.Nature medicine · 2023Pooled it
- Gut bacteria and their metabolites may influence our decisions, intelligence, cognition, and consciousness.Gut microbes · 2026Review
- Article
- Crosstalk between cysteine and lysine modifications: Integrating redox and metabolic regulation.Redox biology · 2026Review
- Reversible alterations of brain acetate metabolism associated with alcohol consumption.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The Gut-Brain Axis in Fetal Alcohol Spectrum Disorder (FASD): Why the Gut Shapes Behavior, Depression, and Self-Injurious Behavior in Children with Prenatal Alcohol Exposure-A Narrative Review with a Proposal for Staged Nutritional and Microbiological Intervention.Journal of clinical medicine · 2026Review
- E2F3a transcription factor mediates behavioral, cellular, and DNA-protein regulation of cocaine reward in the nucleus accumbens.Molecular psychiatry · 2026Article
- Pharmacological Inhibition of HDAC6 Transiently Reduces Voluntary Ethanol Consumption in Male Mice.Alcohol, clinical & experimental research · 2026Article
- ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis.Cancer research · 2026Article
- Greater visceral fat mass accumulation with high alcohol consumption.International journal of obesity (2005) · 2026Article
- Integrative analysis of CUT&Tag-seq and RNA-seq reveals widespread H3K27ac upregulation associated with the activation of muscle-growth-related transcriptional programs in broiler breast muscle.Poultry science · 2026Article
- Ablation of ACSS2 drives alteration to cardiac and hepatic proteomic landscapes in a tissue- and sex-specific manner.Journal of proteomics · 2026Article
- Regulation of Chromatin Acetylation by Alcohol: Dependence on Sex, Brain Region, and Mode of Exposure.Genes · 2026Review
- Epigenetic and Transcriptomic Impacts of Ethanol Vary by Brain Region and Extent of Exposure.eNeuro · 2026Article
- ACSS2 mediates prenatal alcohol exposure-related morphological and behavioral phenotypes.Neurobiology of disease · 2026Article
- Acetate enhances long-term memory in female mice by sex-, context-, and brain region-specific epigenetic and transcriptional remodeling.Science signaling · 2026Article
- Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools.Cell reports · 2026Article
- Addictive drug abuse and depression-a focus on epigenetics.Communications biology · 2026Review
- Processes and therapeutic perspectives of acylation modifications of lysine and cysteine in tumors.Cell communication and signaling : CCS · 2026Review
- The effects of alcohol dependence on the CSF proteome in mice: Evidence for blood-brain barrier dysfunction and neuroinflammation.Neurobiology of disease · 2026Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
P Mews *Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
G Egervari *Epigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. egervari@pennmedicine.upenn.edu.
R NativioEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S SidoliEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
G DonahueEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S I LombrosoEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
D C AlexanderEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S L RiescheEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
E A HellerEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
E J NestlerFishberg Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
B A GarciaEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
S L BergerEpigenetics Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. bergers@pennmedicine.upenn.edu.
University of Pennsylvania · USIcahn School of Medicine at Mount Sinai · US
Funding
Translational Research Support CoreP30ES013508 · NIEHS · UNIVERSITY OF PENNSYLVANIA · PI Rebecca A Simmons · 2006 to 2026
$35.3MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI GARCIA, BENJAMIN A · 2008 to 2022
$28.3MTranscription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Paul J. Kenny · 2019 to 2026
$16.5MPREDOCTORAL TRAINING PROGRAM IN PHARMACOLOGYT32GM008076 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI BLENDY, JULIE A · 1985 to 2023
$10.8MMOLECULAR STUDIES OF COCAINE ACTION IN BRAINR37DA007359 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1996 to 2020
$6.9MMolecular Studies of Cocaine Action in BrainR01DA007359 · NIDA · YALE UNIVERSITY · PI NESTLER, ERIC J. · 1991 to 2025
$5.6MThe metabolic-epigenetic axis in memoryR01AA027202 · NIAAA · UNIVERSITY OF PENNSYLVANIA · PI BERGER, SHELLEY L · 2019 to 2023
$2.2MNIAAA NIH HHS R01 AA027202NIA NIH HHS P01 AG031862NIDA NIH HHS P01 DA047233NIDA NIH HHS R01 DA007359NIDA NIH HHS R37 DA007359NIEHS NIH HHS P30 ES013508NIGMS NIH HHS T32 GM008076
Abstract
Emerging evidence suggests that epigenetic regulation is dependent on metabolic state, and implicates specific metabolic factors in neural functions that drive behaviour
Indexed as
Epigenesis, GeneticAcetatesAcetylationAnimalsBrainChromatinEthanolHippocampusHistonesInjections, IntraperitonealMaleMiceMice, Inbred C57BLPrimary Cell CultureAcetatesChromatinEthanolHistones
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.