Evidence map›Paper›PMID 31645758›Full record

ArticleNature2019

Dietary salt promotes cognitive impairment through tau phosphorylation.

Giuseppe Faraco, Karin Hochrainer, Steven G Segarra, Samantha Schaeffer, Monica M Santisteban, Ajay Menon, Hong Jiang, David M Holtzman, Josef Anrather, Costantino Iadecola

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 138 papers.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed
11.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 220 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Brain endothelial GαEBioMedicine · 2026
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  11. Elevated NaInternational journal of molecular sciences · 2026
    Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. The Ubiquitin-Proteasome System in Brain Disorders: Pathogenic Pathways, Post-Translational Tweaks, and Therapeutic Frontiers.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  17. Elevated NabioRxiv : the preprint server for biology · 2025
    Article
  18. Article
  19. Article
  20. Long Term High-Salt Diet Induces Cognitive Impairments via Down-Regulating SHANK1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article

78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Giuseppe FaracoFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. gif2004@med.cornell.edu.
Karin HochrainerFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Steven G SegarraFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Samantha SchaefferFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Monica M SantistebanFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Ajay MenonFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Hong JiangDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center, Washington University, St. Louis, MO, USA.
Josef AnratherFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Costantino IadecolaFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA. coi2001@med.cornell.edu.
Cornell University · USWeill Cornell Medicine · USHope Center for Neurological Disorders · USMIND Research Institute · US

Funding

Dietary Sodium, Neurovascular Dysfunction and Cerebrovascular RiskR01NS095441 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2016 to 2025
$4.7M
Hypertension and neurovascular dysfunctionR37NS089323 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI IADECOLA, COSTANTINO · 2015 to 2021
$3.1M
Role of CaMKII-alpha ubiquitination in ischemic strokeR01NS109588 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HOCHRAINER, KARIN · 2018 to 2022
$1.9M
NIH HHS 1R01-NS095441NINDS NIH HHS R01 NS095441NINDS NIH HHS R01 NS109588NINDS NIH HHS R37 NS089323
6 · The paper itself

Abstract

Dietary habits and vascular risk factors promote both Alzheimer's disease and cognitive impairment caused by vascular factors

Indexed as

Alzheimer DiseaseAnimalsBrainCognitive DysfunctionHumansMiceMice, KnockoutNeuronsPhosphorylationSodium Chloride, Dietarytau ProteinsSodium Chloride, Dietarytau Proteins

Identifiers

PMID31645758
PMCPMC7380655
OpenAlexW2981842151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.