ArticleNature2019
Heterogeneity in old fibroblasts is linked to variability in reprogramming and wound healing.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 1 pooled it
11.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
165 citing papers in PubMed, 1 synthesis or guideline pooled it, 293 citations in OpenAlex.
- Pooled it
- Effects of Vitamin and Amino Acid-Enriched Hyaluronic Acid Gel on the Healing of Oral Mucosa: In Vivo and In Vitro Study.Medicina (Kaunas, Lithuania) · 2021Trial
- Mechanically Active Adhesive Hydrogels Driven by Peptide Self-Assembly for Accelerated Healing of Diverse Wounds.Advanced healthcare materials · 2026Article
- NodoMap: A single-cell and spatial transcriptomic atlas of the mouse nodose ganglion.Cell press blue · 2026Article
- Cancer-Associated Fibroblasts Promote Epithelial-Mesenchymal Transition and Classical to Basal Subtype Shift in Pancreatic Cancer.Cancer research · 2026Article
- The role and potential therapeutic intervention of cellular senescence in intervertebral disc degeneration.Genes & diseases · 2026Review
- Enhancing the Culture of Mouse Primary Fibroblasts to Study Age-Dependent Effects in Skin Tissue Engineering in vitro.Cells, tissues, organs · 2026Article
- Functional consistency and molecular evolution: a comprehensive characterization of primary endometrial cancer-associated fibroblasts during in vitro expansion.Journal of translational medicine · 2026Article
- NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme KImmunity · 2026Article
- Targeting circulating mechanoresponsive monocytes and macrophages to reduce fibrosis.Nature biomedical engineering · 2026Article
- Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing.Communications biology · 2026Review
- Magnesium phosphate mineralized Ce6 composite hydrogel with photodynamic therapy-mediated antibacterial, anti-inflammatory, and pro-angiogenic properties for application in infected wound healing.Materials today. Bio · 2026Article
- Targeting Cardiac Fibroblast Plasticity for Antifibrotic and Regenerative Therapy in Heart Failure.Cells · 2026Review
- Sulfated Polysaccharides in Wound Healing: From Bioactive Materials Design to Regenerative Therapeutics.International journal of nanomedicine · 2026Review
- Article
- Nucleosome stability safeguards cell identity, stress resilience and healthy aging.Research square · 2025Article
- Intrinsic changes in cell differentiation and identity drive impaired wound healing in aged female murine skin.Biogerontology · 2025Article
- Natural-origin bioadhesive hydrogel with dual antioxidative and immunoregulatory properties for enhanced angiogenesis and wound healing.Bioactive materials · 2025Article
- Fibroblast orchestration of inflammaging via NF-kB activation.bioRxiv : the preprint server for biology · 2025Article
- Nucleosome stability safeguards cell identity, stress resilience and healthy aging.bioRxiv : the preprint server for biology · 2025Article
105 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
19 authors at 2 institutions in 1 country.
Salah Mahmoudi *Department of Genetics, Stanford University, Stanford, CA, USA.
Elena Mancini *Department of Genetics, Stanford University, Stanford, CA, USA.
Lucy XuDepartment of Genetics, Stanford University, Stanford, CA, USA.
Alessandra MooreDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA, USA.
Fereshteh JahanbaniDepartment of Genetics, Stanford University, Stanford, CA, USA.
Katja HebestreitDepartment of Genetics, Stanford University, Stanford, CA, USA.
Rajini SrinivasanInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Xiyan LiDepartment of Genetics, Stanford University, Stanford, CA, USA.
Keerthana DevarajanDepartment of Genetics, Stanford University, Stanford, CA, USA.
Laurie PrélotDepartment of Genetics, Stanford University, Stanford, CA, USA.
Cheen Euong AngInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Yohei ShibuyaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Bérénice A BenayounDepartment of Genetics, Stanford University, Stanford, CA, USA.
Anne Lynn S ChangDepartment of Dermatology, Stanford University, Stanford, CA, USA.
Marius WernigInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Joanna WysockaInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Michael T LongakerDepartment of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University, Stanford, CA, USA.
Michael P SnyderDepartment of Genetics, Stanford University, Stanford, CA, USA.
Anne BrunetDepartment of Genetics, Stanford University, Stanford, CA, USA. anne.brunet@stanford.edu.
Stanford University · USCalifornia Institute for Regenerative Medicine · US
Funding
Wnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI THOMAS A. RANDO · 2011 to 2026
$29.3MStanford Islet Research CoreP30DK116074 · NIDDK · STANFORD UNIVERSITY · PI Seung K Kim · 2017 to 2026
$19.5MProject 3: Effect of Age and Longevity Genes on Epigenomic MechanismsP01GM099130 · NIGMS · STANFORD UNIVERSITY · PI WEISSMAN, SHERMAN MORTON · 2011 to 2015
$11.4MFibroblast lineage mechanisms of scarless skin healingR01GM116892 · NIGMS · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, LORENZ, HERMANN PETER · 2017 to 2020
$1.2MRegulation of transcriptional consistency by broad H3K4me3 domains in young cells and during agingR00AG049934 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BENAYOUN, BERENICE ANATH · 2017 to 2019
$717kUltra high throughput sequencer for sustaining and enhancing multi-scale genomic studiesS10OD025212 · OD · STANFORD UNIVERSITY · PI SNYDER, MICHAEL P. · 2018 to 2018
$600kFour Laser, 18 Color Cell Sorter in the SSFFS10RR025518 · NCRR · STANFORD UNIVERSITY · PI HERZENBERG, LEONARD A · 2009 to 2009
$500kRegulation of transcriptional consistency by broad H3K4me3 domains in young cells and during agingK99AG049934 · NIA · STANFORD UNIVERSITY · PI BENAYOUN, BERENICE ANATH · 2015 to 2016
$191kNCRR NIH HHS S10 RR025518NIA NIH HHS K99 AG049934NIA NIH HHS P01 AG036695NIA NIH HHS R00 AG049934NIDDK NIH HHS P30 DK116074NIGMS NIH HHS P01 GM099130NIGMS NIH HHS R01 GM116892NIH HHS S10 OD025212
Abstract
Age-associated chronic inflammation (inflammageing) is a central hallmark of ageing
Indexed as
Cellular ReprogrammingWound HealingAgingAnimalsCell LineCellular SenescenceCulture Media, ConditionedCytokinesFibroblastsHumansInduced Pluripotent Stem CellsInflammation MediatorsJewsMaleMiceMice, Inbred C57BLCulture Media, ConditionedCytokinesInflammation Mediators
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.