ArticleNature2019
The microbiota regulate neuronal function and fear extinction learning.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
235citing papers in PubMed, 3 pooled it
16.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
235 citing papers in PubMed, 3 syntheses or guidelines pooled it, 422 citations in OpenAlex.
- Relationship Between Depression and Epigallocatechin Gallate from the Perspective of Gut Microbiota: A Systematic Review.Nutrients · 2025Pooled it
- Gut Microbial Community and Host Thermoregulation in Small Mammals.Frontiers in physiology · 2022Pooled it
- Pooled it
- Efficacy and Safety ofNutrients · 2025Trial
- Nutraceutical blends predict enhanced health via microbiota reshaping improving cytokines and life quality: a Brazilian double-blind randomized trial.Scientific reports · 2024Trial
- The neurobiotic sense: emerging pathways of microbial detection and gut-brain communication.Pflugers Archiv : European journal of physiology · 2026Review
- Mild concussion impairs extinction of avoidance and alters respective brain circuits in male rats.Experimental neurology · 2026Article
- Microglia-dependent regulation of fear memory extinction.Nature neuroscience · 2026Article
- Extracellular matrix remodelling in neurological diseases.Nature reviews. Neurology · 2026Review
- A defined community of core gut microbiota members promotes cognitive performance in honey bees.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Microbiome Integrity Protects Against Glial-Mediated Tau and Amyloid Pathology Through Circadian and Autophagy Homeostasis.bioRxiv : the preprint server for biology · 2026Article
- The Gut-Brain Axis in Post-Traumatic Stress Disorder: From Biological Mechanisms to Microbiome-Based Therapeutic Strategies-A Narrative Review.Microorganisms · 2026Review
- Panacis Quinquefolii Radix Polysaccharides Alleviate Depressive-Like Behaviors in Chronic Unpredictable Mild Stress-Induced Mice by Suppressing Complement C1Q/C3-Mediated Microglial Synaptic Pruning and Modulating Gut Microbiota.CNS neuroscience & therapeutics · 2026Article
- Gut microbiome community structure correlates with different behavioral phenotypes in the Belyaev Farm-Fox Experiment.Communications biology · 2026Article
- The gut as a central hub for multi-organ crosstalk in aging.Cellular and molecular life sciences : CMLS · 2026Review
- Acute Estradiol Bridges Gut Microbiome Composition With Cognition.Biological psychiatry global open science · 2026Article
- Interactions Between Perioperative Anesthesia Management and Gut Microbiota: Current Research Advances.Cellular and molecular neurobiology · 2026Review
- Microbiota utilization of intestinal amino acids modulates cancer progression and anticancer immunity.Cell host & microbe · 2026Article
- Maternal gestational diabetes mellitus leads to adverse growth patterns and disease risk in offspring in vivo: evidence from cross-generational effects on gut microbiota.BMC microbiology · 2026Article
- Gut Microbiome-Sphingolipid Metabolism-Brain Axis Interactions: Neuroprotective Effects of Amitriptyline as Functional Inhibitor of Acid Sphingomyelinase in a Mouse Model of Tauopathy.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2026Article
175 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
24 authors at 6 institutions in 1 country.
Coco ChuJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Mitchell H MurdockFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Deqiang JingDepartment of Psychiatry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Tae Hyung WonBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Hattie ChungKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Adam M KresselCenter for Biomedical Science and Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Tea TsaavaCenter for Biomedical Science and Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Meghan E AddorisioCenter for Biomedical Science and Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Gregory G PutzelJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Lei ZhouJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Nicholas J BessmanJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Ruirong YangDepartment of Psychiatry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Saya MoriyamaJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Christopher N ParkhurstJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Anfei LiDepartment of Psychiatry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Heidi C MeyerDepartment of Psychiatry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Fei TengJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Sangeeta S ChavanCenter for Biomedical Science and Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Kevin J TraceyCenter for Biomedical Science and Bioelectronic Medicine, Feinstein Institute for Medical Research, Northwell Health, Manhasset, NY, USA.
Aviv RegevKlarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Francis S LeeDepartment of Psychiatry, Weill Cornell Medicine, Cornell University, New York, NY, USA.
Conor ListonFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, Cornell University, New York, NY, USA. col2004@med.cornell.edu.
David ArtisJill Roberts Institute for Research in Inflammatory Bowel Disease, Weill Cornell Medicine, Cornell University, New York, NY, USA. dartis@med.cornell.edu.
Cornell University · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USFeinstein Institute for Medical Research · USBroad Institute · USHoward Hughes Medical Institute · USNorthwell Health · US
Funding
Targeting cognitive and immune impairment in sepsis survivorsP01AI102852 · NIAID · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI DIAMOND, BETTY · 2014 to 2018
$11.5MRegulation of protective immunity following enteric viral infectionU01AI095608 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID, SONNENBERG, GREGORY F · 2011 to 2025
$11.0MMolecular Basis of Bioelectronic MedicineR35GM118182 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI TRACEY, KEVIN J · 2016 to 2025
$7.3MRegulation of prefrontal cortical circuit function and reward-seeking behavior by stress-induced dendritic spine remodelingR01MH118451 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI Joshua Levitz, Conor M Liston · 2019 to 2026
$5.5MThe Impact of the BDNF Val66Met Prodomain on Cognitive Function in a Mouse Model of Alzheimer's DiseaseR01NS052819 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI HEMPSTEAD, BARBARA L, LEE, FRANCIS SANG YONG · 2005 to 2019
$5.3MInnate immunity and inflammation following helminth infectionR01AI074878 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2008 to 2019
$4.2MRegulation and function of innate lymphoid cells in the gutR01AI095466 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2011 to 2022
$3.7MNeuropeptide-mediated regulation of antihelminth immunityR01AI151599 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI ARTIS, DAVID, SIRACUSA, MARK CHRISTOPHER · 2020 to 2024
$3.2MNeuro-immune regulation of intestinal inflammationR01DK126871 · NIDDK · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2020 to 2024
$3.2MPrefrontal Cortical Microcircuit Mechanisms of Working Memory Deficits in Chronic StressR01MH109685 · NIMH · WEILL MEDICAL COLL OF CORNELL UNIV · PI LISTON, CONOR M · 2016 to 2020
$2.8MRegulation and function of innate lymphoid cells during influenza virus infectionR01AI102942 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI ARTIS, DAVID · 2013 to 2017
$2.1MThe ion channel TRPA1 is required for suppression of inflammation in sepsisR01GM132672 · NIGMS · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI CHAVAN, SANGEETA S. · 2019 to 2025
$1.7MNIAID NIH HHS F32 AI124517NIAID NIH HHS P01 AI102852NIAID NIH HHS R01 AI074878NIAID NIH HHS R01 AI095466NIAID NIH HHS R01 AI102942NIAID NIH HHS R01 AI151599NIAID NIH HHS R21 AI142213NIAID NIH HHS U01 AI095608NIDDK NIH HHS R01 DK126871NIGMS NIH HHS R01 GM132672NIGMS NIH HHS R35 GM118182NIMH NIH HHS R01 MH109685NIMH NIH HHS R01 MH118451NINDS NIH HHS R01 NS052819
Abstract
Multicellular organisms have co-evolved with complex consortia of viruses, bacteria, fungi and parasites, collectively referred to as the microbiota
Indexed as
MetabolomicsAnimalsAnti-Bacterial AgentsAutistic DisorderBloodCalciumCerebrospinal FluidCuesDendritic SpinesExtinction, PsychologicalFearFecesGerm-Free LifeIndicanMaleMice3-(3-hydroxyphenyl)-3-hydroxypropanoic acidAnti-Bacterial AgentsCalciumIndicanPhenylpropionates
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.