ArticleEye (London, England)2020
Structural consequences of arrested foveal development in preterms with persisting signs of immaturity.
Article in Eye (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Effect of Prematurity on Foveal Development During Infancy: Increased Foveal Inner and Outer Retina Layer Thicknesses in Extremely Premature Infants.Investigative ophthalmology & visual science · 2026Observational
- Skin Melanin Content and the Foveal Avascular Zone Correlation in a Healthy White Population.Investigative ophthalmology & visual science · 2026Article
- Visual pathway function in adults born preterm with very low birth weight: a two-country birth cohort study.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Unusual morphology of foveal Müller glia in an adult human born pre-term.Frontiers in cellular neuroscience · 2024Article
- Potential application of foveal structural measurements in treatment decision for retinopathy of prematurity: an OCT-based study.International journal of retina and vitreous · 2023Article
- Structural impact of arrested foveal development in children born extremely preterm without ROP at 6.5 years of age.Eye (London, England) · 2023Article
- Insights into the developing fovea revealed by imaging.Progress in retinal and eye research · 2022Review
- Characterization of Foveal Development in Treatment-Naïve Extremely Preterm Infants.Translational vision science & technology · 2022Article
- Foveal Differentiation and Inner Retinal Displacement Are Arrested in Extremely Premature Infants.Investigative ophthalmology & visual science · 2021Observational
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the impact of structural changes in a limited sample of adult preterms with foveal immaturity from optical coherence tomography (OCT) B-scan images and to estimate layer displacement and changes in areal and volume magnification within the inner fovea. SUBJECTS AND
methodsLayer thickness was measured in conventional and directional OCT scans from eight preterms with different degrees of foveal immaturity (24-33 weeks of gestation, 22-33 years of age) and five controls (20-33 years of age). We obtained reflectivity profiles of the outer plexiform layer (OPL) and manual segmentation data of the inner nuclear layer (INL) and the combined ganglion cell layer (GCL) and inner plexiform layer (IPL) at specified eccentricities from 300 to 900 µm. Displacement of cumulative thickness curves of preterms compared with that of the controls was used to estimate retardation of layer displacement. Changes in areal magnification and layer thickness were used to construct a structural model of redistribution within the fovea of preterms.
resultsRetardation of centrifugal layer displacement of OPL and all inner retinal layers (IRL) was marked in both preterm groups with foveal immaturity, whereas retardation was marginal in the preterm group without clinical signs of immaturity. Retarded displacement within the IRL and OPL had a major impact on available space within the central fovea.
conclusionsA marked retardation of displacement was demonstrated for all IRL within the immature fovea of preterms with decreased areal and volume magnification and reduced space available for synaptic communication coupled to the degree of immaturity.
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