Evidence map›Paper›PMID 31645660›Full record

ArticleActa pharmacologica Sinica2020

Propofol affects mouse embryonic fibroblast survival and proliferation in vitro via ATG5- and calcium-dependent regulation of autophagy.

Zhen-Dong Xu, Yong Wang, Ge Liang, Zhi-Qiang Liu, Wu-Hua Ma, Charleen T Chu, Hua-Feng Wei

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta pharmacologica Sinica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Zhen-Dong XuDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Yong WangDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ge LiangDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Zhi-Qiang LiuDepartment of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, 201204, China.
Wu-Hua MaDepartment of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 510545, China.
Charleen T ChuDepartment of Pathology, Division of Neuropathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Hua-Feng WeiDepartment of Anesthesiology and Critical Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA. weih@uphs.upenn.edu.
University of Pennsylvania · USFirst Affiliated Hospital of Guangzhou University of Chinese Medicine · CNShanghai First Maternity and Infant Hospital · CNUniversity of Pittsburgh · US

Funding

Regulation of Autophagy & Mitochondrial Recycling in Neuronal Cell Death- SupplementR01AG026389 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHU, CHARLEEN T · 2007 to 2024
$6.0M
Mechanisms of Anesthesia Mediated NeurotoxicityR01GM084979 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WEI, HUAFENG · 2008 to 2018
$2.8M
Mechanisms of Dantrolene Neuroprotection in Alzheimer's DiseaseR01AG061447 · NIA · UNIVERSITY OF PENNSYLVANIA · PI WEI, HUAFENG · 2019 to 2023
$2.3M
NIA NIH HHS R01 AG026389NIA NIH HHS R01 AG061447NIGMS NIH HHS R01 GM084979
6 · The paper itself

Abstract

Propofol is a commonly used intravenous anesthetic agent, which has been found to affect cell survival and proliferation especially in early life. Our previous studies show that propofol-induced neurodegeneration and neurogenesis are closely associated with cell autophagy. In the present study we explored the roles of autophagy-related gene 5 (ATG5) in propofol-induced autophagy in mouse embryonic fibroblasts (MEF) in vitro. We showed that ATG5 was functionally related to propofol-induced cell survival and damage: propofol significantly enhanced cell survival and proliferation at a clinically relevant dose (10 µM), but caused cell death at an extremely high concentration (200 µM) in ATG5

Indexed as

Anesthetics, IntravenousAnimalsAutophagyAutophagy-Related Protein 5CalciumCell ProliferationCells, CulturedCell SurvivalDose-Response Relationship, DrugFibroblastsMiceMice, KnockoutPropofolStructure-Activity RelationshipAnesthetics, IntravenousAtg5 protein, mouseAutophagy-Related Protein 5CalciumPropofolATG5autophagycalciumInsP3 receptorsmouse embryonic fibroblastspropofolryanodine receptors

Identifiers

PMID31645660
PMCPMC7471456
OpenAlexW2981894146

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.