Evidence map›Paper›PMID 31645647›Full record

ArticleLeukemia2020

Thiopurine-mediated impairment of hematopoietic stem and leukemia cells in Nudt15

Goichi Tatsumi, Masahiro Kawahara, Takayuki Imai, Ai Nishishita-Asai, Atsushi Nishida, Osamu Inatomi, Akihiko Yokoyama, Yoichi Kakuta, Katsuyuki Kito, Akira Andoh

Abstract read
PubMed Publisher
In one paragraph

Article in Leukemia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Medical sciences (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
  4. The frequency ofFrontiers in oncology · 2024
    Article
  5. Article
  6. Review
  7. The Effect ofChildren (Basel, Switzerland) · 2021
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Goichi Tatsumi *Division of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.ORCID http://orcid.org/0000-0001-5886-2381
Masahiro Kawahara *Division of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan. mkawahar@belle.shiga-med.ac.jp.ORCID http://orcid.org/0000-0002-2721-7571
Takayuki Imai *Division of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Ai Nishishita-AsaiDivision of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Atsushi NishidaDivision of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Osamu InatomiDivision of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Akihiko YokoyamaTsuruoka Metabolomics Laboratory, National Cancer Center, Yamagata, Japan.
Yoichi KakutaDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Miyagi, Japan.ORCID http://orcid.org/0000-0002-7042-009X
Katsuyuki KitoDivision of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Akira AndohDivision of Gastroenterology and Hematology, Department of Medicine, Shiga University of Medical Science, Shiga, Japan.
Shiga University of Medical Science · JPNational Institute of Technology, Tsuruoka College · JPTohoku University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Thiopurines are widely used as antileukemia agents and immunosuppressants. Recent large-scale clinical studies revealed a strong association between the NUDT15 p.Arg139Cys (NUDT15

Indexed as

AnimalsDNA RepairFemaleFlow CytometryGene Knock-In TechniquesGenotypeHematopoietic Stem CellsHumansLeukemiaLeukopeniaMaleMercaptopurineMiceMice, Inbred C57BLMice, TransgenicNudix HydrolasesMercaptopurineNudix HydrolasesNUDT15 protein, humanNudt15 protein, mousePyrophosphatases

Identifiers

PMID31645647
OpenAlexW2982272005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.