Evidence map›Paper›PMID 31645637›Full record

SynthesisScientific reports2019

Genome-wide association meta-analysis identifies five novel loci for age-related hearing impairment.

Andries Paul Nagtegaal, Linda Broer, Nuno R Zilhao, Johanna Jakobsdottir, Charles E Bishop, Marco Brumat, Mark W Christiansen, Massimiliano Cocca, Yan Gao, Nancy L Heard-Costa and 32 more

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
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  6. Pharmacological Approaches to Hearing Loss.Pharmacological reviews · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

42 authors at 19 institutions in 6 countries.

Andries Paul NagtegaalDepartment of Otorhinolaryngology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. a.nagtegaal@erasmusmc.nl.ORCID http://orcid.org/0000-0001-8128-7178
Linda BroerDepartment of Internal Medicine, Erasm us Medical Center, 3015 CE, Rotterdam, The Netherlands.
Nuno R ZilhaoIcelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland.
Johanna JakobsdottirIcelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland.
Charles E BishopDepartment of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Marco BrumatDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Mark W ChristiansenCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Massimiliano CoccaMedical Genetics, Institute for Maternal and Child Health, IRCCS "Burlo Garofolo", Trieste, Italy.ORCID http://orcid.org/0000-0002-1127-7596
Yan GaoDepartment of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Nancy L Heard-CostaNHLBI Framingham Heart Study, Framingham, MA, 01702, USA.ORCID http://orcid.org/0000-0001-9730-0306
Daniel S EvansDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158, USA.
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Sheila R PrattDepartment of Communication Science & Disorders, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA, 15260, USA.
T Ryan PriceLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, 20892, USA.
Christopher SpankovichDepartment of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Mary R StimsonDepartment of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.
Karen ValleJackson Heart Study, 350 W. Woodrow Wilson Blvd, Suite 701, Jackson, MS, 39213, USA.
Dragana VuckovicDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Helena WellsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Gudny EiriksdottirIcelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland.
Erik FransenCenter for Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43/6, BE-2650, Edegem, Antwerp, Belgium.
Mohammad Arfan IkramDepartment of Epidemiology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
Chuang-Ming LiEpidemiology and Statistics Program, Division of Scientific Programs, National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health (NIH), Neuroscience Center Building, Suite 8300, 6001 Executive Blvd, Bethesda, MD, 20892, USA.
W T LongstrethDepartments of Neurology and Epidemiology, University of Washington, Seattle, WA, 98195, USA.
Claire StevesDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
Guy Van CampCenter for Medical Genetics, University of Antwerp, Prins Boudewijnlaan 43/6, BE-2650, Edegem, Antwerp, Belgium.
Adolfo CorreaJackson Heart Study, 350 W. Woodrow Wilson Blvd, Suite 701, Jackson, MS, 39213, USA.ORCID http://orcid.org/0000-0002-9501-600X
Karen J CruickshanksDepartments of Ophthalmology and Visual Sciences and Population Health Sciences, University of Wisconsin, Madison, WI, 53726, USA.
Paolo GaspariniDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Giorgia GirottoDepartment of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.ORCID http://orcid.org/0000-0003-4507-6589
Robert C KaplanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.
Michael NallsData Tecnica International, Glen Echo, MD, 20812, USA.
John M SchweinfurthDepartment of Otolaryngology and Communicative Sciences, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Sudha SeshadriGlenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, UT Health, San Antonio, 78229, TX, USA.
Nona SotoodehniaCardiovascular Health Research Unit, University of Washington, Seattle, WA, 98195, USA.
Gregory J TranahDepartment of Epidemiology and Biostatistics, University of California, San Francisco, CA, 94158, USA.
André G UitterlindenDepartment of Internal Medicine, Erasm us Medical Center, 3015 CE, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-7276-3387
James G WilsonDepartment of Physiology and Biophysics, The University of Mississippi Medical Center, 2500 North State Street, Jackson, MS, 39216, USA.
Vilmundur GudnasonIcelandic Heart Association, Holtasmari 1, Kopavogur, IS-201, Iceland.ORCID http://orcid.org/0000-0001-5696-0084
Howard J HoffmanEpidemiology and Statistics Program, Division of Scientific Programs, National Institute on Deafness and Other Communication Disorders (NIDCD) National Institutes of Health (NIH), Neuroscience Center Building, Suite 8300, 6001 Executive Blvd, Bethesda, MD, 20892, USA.
Frances M K WilliamsDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
André GoedegebureDepartment of Otorhinolaryngology, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands.
State Street (United States) · USIcelandic Heart Association · ISUniversity of Trieste · ITErasmus MC · NLKing's College London · GBUniversity of Washington · USJackson Memorial Hospital · USNational Institutes of Health · USUniversity of Antwerp · BEUniversity of California, San Francisco · USUniversity of Minnesota · USAlbert Einstein College of Medicine · USData Tecnica International (United States) · USFramingham Heart Study · USInstitute for Neurodegenerative Disorders · USIRCCS Materno Infantile Burlo Garofolo · ITNational Institute on Aging · USUniversity of Pittsburgh · USUniversity of Wisconsin–Madison · US

Funding

CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Rare variants and NHLBI traits in deeply phenotyped cohortsR01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2014 to 2016
$8.9M
Rare variants and NHLBI traits in deeply phenotyped cohortsU01HL120393 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M, RICE, KENNETH M. · 2017 to 2018
$5.6M
Integrative Resource to Develop Translational Strategies to Promote LongevityU24AG051129 · NIA · CALIFORNIA PACIFIC MED CTR RES INSTITUTE · PI CUMMINGS, STEVEN RON, EVANS, DANIEL SPENCER · 2015 to 2019
$5.3M
NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL120393NHLBI NIH HHS U01 HL120393NIA NIH HHS U24 AG051129
6 · The paper itself

Abstract

Previous research has shown that genes play a substantial role in determining a person's susceptibility to age-related hearing impairment. The existing studies on this subject have different results, which may be caused by difficulties in determining the phenotype or the limited number of participants involved. Here, we have gathered the largest sample to date (discovery n = 9,675; replication n = 10,963; validation n = 356,141), and examined phenotypes that represented low/mid and high frequency hearing loss on the pure tone audiogram. We identified 7 loci that were either replicated and/or validated, of which 5 loci are novel in hearing. Especially the ILDR1 gene is a high profile candidate, as it contains our top SNP, is a known hearing loss gene, has been linked to age-related hearing impairment before, and in addition is preferentially expressed within hair cells of the inner ear. By verifying all previously published SNPs, we can present a paper that combines all new and existing findings to date, giving a complete overview of the genetic architecture of age-related hearing impairment. This is of importance as age-related hearing impairment is highly prevalent in our ageing society and represents a large socio-economic burden.

Indexed as

Genetic LociGenetic Predisposition to DiseaseGenome-Wide Association StudyAgingAnimalsAuditory PathwaysFemaleGene Expression RegulationHearing LossHumansMaleMiceMiddle AgedMolecular Sequence AnnotationPhenotypeReproducibility of Results

Identifiers

PMID31645637
PMCPMC6811684
OpenAlexW2982029879

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.