ArticleScientific reports2019
Intranasal oxytocin selectively modulates the behavior of rhesus monkeys in an expression matching task.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Oxytocin in the Amygdala Sustains Prosocial Behavior via State-Dependent Amygdala-Prefrontal Modulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- How Do Common Marmosets Maintain the Balance Between Response Execution and Action Inhibition?American journal of primatology · 2025Article
- Beyond faces: the contribution of the amygdala to visual processing in the macaque brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Preliminary evidence of an increased susceptibility to face pareidolia in postpartum women.Biology letters · 2023Article
- A database of heterogeneous faces for studying naturalistic expressions.Scientific reports · 2023Article
- The cortical and subcortical correlates of face pareidolia in the macaque brain.Social cognitive and affective neuroscience · 2022Article
- Oxytocin-based therapies for treatment of Prader-Willi and Schaaf-Yang syndromes: evidence, disappointments, and future research strategies.Translational psychiatry · 2022Review
- Oxytocin promotes prosocial behavior and related neural responses in infant macaques at-risk for compromised social development.Developmental cognitive neuroscience · 2021Article
- What does a "face cell" want?'Progress in neurobiology · 2020Article
- Parallel Processing of Facial Expression and Head Orientation in the Macaque Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the neuropeptide oxytocin (OT) is thought to regulate prosocial behavior in mammals, there is considerable debate as to how intranasal OT influences primate behavior. The aim of this study was to determine whether intranasal OT has a general anxiolytic effect on the performance of rhesus monkeys tasked with matching face stimuli, or a more selective effect on their behavior towards aversive facial expressions. To this end, we developed an innovative delayed match-to-sample task where the exact same trials could be used to assess either a monkey's ability to match facial expressions or facial identities. If OT has a general affect on behavior, then performance in both tasks should be altered by the administration of OT. We tested four male rhesus monkeys (Macaca mulatta) in both the expression and identity task after the intranasal administration of either OT or saline in a within-subjects design. We found that OT inhalation selectively reduced a selection bias against negatively valenced expressions. Based on the same visual input, performance in the identity task was also unaffected by OT. This dissociation provides evidence that intranasal OT affects primate behavior under very particular circumstances, rather than acting as a general anxiolytic, in a highly translatable nonhuman model, the rhesus monkey.
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