ArticleNature communications2019
Context-dependent limb movement encoding in neuronal populations of motor cortex.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 52 citations in OpenAlex.
- Complementary cortical and thalamic contributions to cell type-specific striatal activity dynamics during movement.Science advances · 2026Article
- Widefield cortical activity and functional connectivity during motorized locomotion.Communications biology · 2026Article
- Encoding of motor sequences in primate globus pallidus and motor cortex: Uniform preference for ordinal position.bioRxiv : the preprint server for biology · 2025Article
- Two premotor areas (6aα and 6aγ) involved in motor preparation and execution during visually guided locomotion in the cat.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Human motor cortex encodes complex handwriting through a sequence of stable neural states.Nature human behaviour · 2025Article
- Neural representation of self-initiated locomotion in the secondary motor cortex of mice across different environmental contexts.Communications biology · 2025Article
- Brain-wide microstrokes affect the stability of memory circuits in the hippocampus.Nature communications · 2025Article
- Whether or not to act is determined by distinct signals from motor thalamus and orbitofrontal cortex to secondary motor cortex.Nature communications · 2025Article
- Parvalbumin interneurons regulate rehabilitation-induced functional recovery after stroke and identify a rehabilitation drug.Nature communications · 2025Article
- Organizational Principles of the Primate Cerebral Cortex at the Single-Cell Level.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Learning and Control in Motor Cortex across Cell Types and Scales.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Information flow between motor cortex and striatum reverses during skill learning.Current biology : CB · 2024Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Layer 5 Intratelencephalic Neurons in the Motor Cortex Stably Encode Skilled Movement.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Article
- Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke.iScience · 2023Article
- Uncovering the shared molecule and mechanism between ulcerative colitis and atherosclerosis: an integrative genomic analysis.Frontiers in immunology · 2023Article
- A robust role for motor cortex.Frontiers in neuroscience · 2023Article
- Multiple regions of sensorimotor cortex encode bite force and gape.Frontiers in systems neuroscience · 2023Article
- A secondary motor area contributing to interlimb coordination during visually guided locomotion in the cat.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuronal networks of the mammalian motor cortex (M1) are important for dexterous control of limb joints. Yet it remains unclear how encoding of joint movement in M1 depends on varying environmental contexts. Using calcium imaging we measured neuronal activity in layer 2/3 of the M1 forelimb region while mice grasped regularly or irregularly spaced ladder rungs during locomotion. We found that population coding of forelimb joint movements is sparse and varies according to the flexibility demanded from individual joints in the regular and irregular context, even for equivalent grasping actions across conditions. This context-dependence of M1 encoding emerged during task learning, fostering higher precision of grasping actions, but broke apart upon silencing of projections from secondary motor cortex (M2). These findings suggest that M1 exploits information from M2 to adapt encoding of joint movements to the flexibility demands of distinct familiar contexts, thereby increasing the accuracy of motor output.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.