ArticleNature communications2019
Dissecting the molecular evolution of fluoroquinolone-resistant Shigella sonnei.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
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Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Whole genome sequencing analysis of antibiotic resistant genes of Shigella species: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Virulence factors and antimicrobial resistance of uropathogenic Escherichia coli (UPEC) isolated from urinary tract infections: a systematic review and meta-analysis.BMC infectious diseases · 2021Pooled it
- Non-Traditional Antibacterial Agents Relevant to the WHO 2024 Priority Pathogens: A Structured Update of the Clinical Pipeline.Antibiotics (Basel, Switzerland) · 2026Review
- Reduced MGE burden, virulence optimization, and acid stress tolerance shape the clonal succession of MRSA ST59.Science advances · 2026Article
- Emergence and genomic adaptation of the globally disseminated ST2250 lineage within theAntimicrobial agents and chemotherapy · 2026Article
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- A public resource of 15 genomically characterized representative strains ofMicrobial genomics · 2026Article
- Genomic insights into the rapid rise ofVirulence · 2025Article
- Epidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England.Emerging infectious diseases · 2025Article
- Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.Nature communications · 2025Article
- A three-dimensional high throughput assay identifies novel antibacterial molecules with activity against intracellular Shigella.npj antimicrobials and resistance · 2025Article
- The rise in domestic shigellosis and the genomic characteristics ofMicrobiology spectrum · 2025Article
- Molecular epidemiology of a multidrug-resistantMicrobial genomics · 2025Article
- Understanding and addressing β-lactam resistance mechanisms in gram-negative bacteria in Lebanon: A scoping review.Heliyon · 2025Review
- The pivotal role of IncFIB(Mar) plasmid in the emergence and spread of hypervirulent carbapenem-resistantScience advances · 2025Article
- AnalyzingInfection and drug resistance · 2025Article
- Prevalence of plasmid-mediated quinolone resistance genes and biofilm formation in different species of quinolone-resistant clinical Shigella isolates: a cross-sectional study.European journal of medical research · 2024Article
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- Is Shigella an under-recognized pathogen? A case of pyogenic cervical spondylitis caused byIDCases · 2024Article
- Pathogenicity and virulence ofVirulence · 2023Review
Corrections and comments
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Authors and funding
25 authors.
Funding
Abstract
Shigella sonnei increasingly dominates the international epidemiological landscape of shigellosis. Treatment options for S. sonnei are dwindling due to resistance to several key antimicrobials, including the fluoroquinolones. Here we analyse nearly 400 S. sonnei whole genome sequences from both endemic and non-endemic regions to delineate the evolutionary history of the recently emergent fluoroquinolone-resistant S. sonnei. We reaffirm that extant resistant organisms belong to a single clonal expansion event. Our results indicate that sequential accumulation of defining mutations (gyrA-S83L, parC-S80I, and gyrA-D87G) led to the emergence of the fluoroquinolone-resistant S. sonnei population around 2007 in South Asia. This clone was then transmitted globally, resulting in establishments in Southeast Asia and Europe. Mutation analysis suggests that the clone became dominant through enhanced adaptation to oxidative stress. Experimental evolution reveals that under fluoroquinolone exposure in vitro, resistant S. sonnei develops further intolerance to the antimicrobial while the susceptible counterpart fails to attain complete resistance.
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