ArticleAging2019
Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment.
Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Disruptive resting state networks characterizing depressive comorbidity in Alzheimer's disease and mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Pooled it
- Neuroimaging studies of acupuncture on Alzheimer's disease: a systematic review.BMC complementary medicine and therapies · 2023Pooled it
- An Activation Likelihood Estimation Meta-Analysis of Specific Functional Alterations in Dorsal Attention Network in Mild Cognitive Impairment.Frontiers in neuroscience · 2022Pooled it
- Network-based transcranial direct current stimulation may improve gait and cognitive function in older adults: a randomized controlled crossover study.BMC geriatrics · 2025Trial
- Neuromodulation techniques targeting neurotransmitter dysfunction: Innovation in treatments for Alzheimer's disease.Neural regeneration research · 2026Article
- Cognitive Vergence and Pupil Response During Oddball Task are Associated With Alzheimer's Disease Cerebrospinal Fluid Neurodegenerative Biomarkers.bioRxiv : the preprint server for biology · 2026Article
- Environmental Enrichment Preserves Retrosplenial Parvalbumin Density and Cognitive Function in Female 5xFAD Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Posterior cortical atrophy: reorganization of the dorsal attention network and its implications on volume loss and clinical performance.Journal of neurology · 2025Article
- Co-Community Network Analysis Reveals Alterations in Brain Networks in Alzheimer's Disease.Brain sciences · 2025Article
- Default Mode Network Functional Connectivity As a Transdiagnostic Biomarker of Cognitive Function.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Compensation versus deterioration across functional networks in amnestic mild cognitive impairment subtypes.GeroScience · 2025Article
- Disruption of global brain network topology in amnestic MCI: evidence from multimodal DTI and fMRI.Frontiers in neuroscience · 2025Article
- Specificity of functional network connectivity during the AD prodromal phase in mild cognitive impairment.Frontiers in psychiatry · 2025Article
- Hyperbolic Graph Embedding of MEG Brain Networks to Study Brain Alterations in Individuals With Subjective Cognitive Decline.IEEE journal of biomedical and health informatics · 2024Article
- Alterations in large-scale resting-state network nodes following transcranial focused ultrasound of deep brain structures.Frontiers in human neuroscience · 2024Article
- Comparison of autism spectrum disorder subtypes based on functional and structural factors.Frontiers in neuroscience · 2024Article
- Detection of neurophysiological markers of cognitive reserve: an EEG study.Frontiers in aging neuroscience · 2024Article
- Comparison of the diagnostic accuracy of resting-state fMRI driven machine learning algorithms in the detection of mild cognitive impairment.Scientific reports · 2023Article
- Hyperbolic graph embedding of MEG brain networks to study brain alterations in individuals with subjective cognitive decline.bioRxiv : the preprint server for biology · 2023Article
- Resting-state MRI functional connectivity as a neural correlate of multidomain lifestyle adherence in older adults at risk for Alzheimer's disease.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An anticorrelated relationship in the spontaneous fluctuations between the default mode network (DMN) and dorsal attention network (DAN) is a robust feature of intrinsic brain organization in healthy individuals. Prior studies have reported a decreased anticorrelation between the DMN and the DAN in Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, it is unclear how this anticorrelation changes as MCI progresses to AD. We hypothesized that dysfunctional connectivity between the DMN and DAN may reflect the gradual decline from MCI to AD. To test this hypothesis, we investigated alterations in functional connectivity between the DMN and DAN in subtypes of amnestic MCI (aMCI) by comparing with the same functional pattern in healthy elderly individuals and patients with AD. We retrospectively collected brain imaging and neuropsychological data from 20 AD participants, 22 participants with multiple-domain aMCI (aMCI-m), 29 participants with single-domain aMCI (aMCI-s) and 23 sex-matched normal controls in this study. Resting-state functional connectivity analysis revealed that aMCI-s and aMCI-m groups demonstrated different magnitudes of increased anticorrelation between the DMN and DAN relative to the AD group. Furthermore, in aMCI-s, aMCI-m and AD participants, hypoconnectivity was found in specific regions within the DMN, including the precuneus and angular gyrus, and hyperconnectivity was found in areas outside the typical DMN networks, including the middle occipital gyrus, lingual gyrus and visual cortex, which indicated disease-related adaptations of brain networks. Our findings suggest that DMN-DAN anticorrelation may shed light on the understanding of the adaptations in brain function during the progression from MCI to AD and may serve as a potential biomarker to detect AD in the preclinical stage.
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