A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses.
Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors at 4 institutions in 2 countries.
Alexander S Hahn *Junior Research Group Herpesviruses, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany ahahn@dpz.eu r.desrosiers@med.miami.edu.ORCID 0000-0003-4171-2744
Georg F Bischof *Department of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Anna K GroßkopfJunior Research Group Herpesviruses, German Primate Center-Leibniz Institute for Primate Research, Göttingen, Germany.
Young C ShinDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Aline DominguesDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Lucas Gonzalez-NietoDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Eva G RakaszWisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.
David I WatkinsDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.
Armin EnsserInstitute of Clinical and Molecular Virology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.ORCID 0000-0001-8873-3863
Mauricio A MartinsDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA.ORCID 0000-0001-8336-216X
Ronald C DesrosiersDepartment of Pathology, Miller School of Medicine, University of Miami, Miami, Florida, USA ahahn@dpz.eu r.desrosiers@med.miami.edu.ORCID 0000-0001-6851-3003
University of Miami · USGerman Primate Center · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEUniversity of Wisconsin–Madison · US
Funding
WNPRC Supplemental Request for Nonhuman Primate Enclosures to Equip HIV/AIDS-Related Research FacilitiesP51OD011106 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI Dorota A. Grejner-Brzezinska · 2012 to 2026
$150.7M
The Functional Significance of Cytotoxic T Lymphocyte EscapeR01AI052056 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 2003 to 2024
$8.3M
The Functional Significance of CTL EscapeR37AI052056 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI WATKINS, DAVID I · 2008 to 2017
$7.1M
Gamma-2 Herpesviruses as Vaccine Vectors for AIDSR37AI063928 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI DESROSIERS, RONALD C · 2013 to 2022
$5.1M
Can vaccine-induced CD8 T cells prevent chronic phase AIDS virus replication?R01AI108421 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI WATKINS, DAVID I · 2014 to 2018
$2.9M
Rhesus Monkey Rhadinovirus Glycoproteins, Entry, and NeutralizationR01AI072004 · NIAID · HARVARD MEDICAL SCHOOL · PI DESROSIERS, RONALD C · 2008 to 2012
$1.9M
Ipilimumab as an adjuvant for HIV vaccinesK01OD023032 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MARTINS, MAURICIO DE AGUIAR · 2016 to 2018
A replication-competent, recombinant strain of rhesus monkey rhadinovirus (RRV) expressing the Gag protein of SIVmac239 was constructed in the context of a glycoprotein L (gL) deletion mutation. Deletion of gL detargets the virus from Eph family receptors. The ability of this gL-minus Gag recombinant RRV to infect, persist, and elicit immune responses was evaluated after intravenous inoculation of two
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
A Recombinant Rhesus Monkey Rhadinovirus Deleted of Glycoprotein L Establishes Persistent Infection of Rhesus Macaques and Elicits Conventional T Cell Responses. · full record | OpenQuestion