Evidence map›Paper›PMID 31645447›Full record

ArticleJournal of virology2020

Differential Expression of Immune Checkpoint Molecules on CD8

Kate L Carroll, Lyndsay Avery, Benjamin R Treat, Lawrence P Kane, Paul R Kinchington, Robert L Hendricks, Anthony J St Leger

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Herpes Simplex Virus 1-Specific CD8Journal of virology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kate L CarrollDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-3867-2892
Lyndsay AveryDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8148-1648
Benjamin R TreatDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-3385-0250
Lawrence P KaneDepartment of Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-5198-516X
Paul R KinchingtonDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1901-9970
Robert L HendricksDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-7419-2912
Anthony J St LegerDepartment of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA anthony.stleger@pitt.edu.ORCID 0000-0002-2547-200X
University of Pittsburgh · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Ethan A Rossi · 1989 to 2026
$17.8M
ROLE OF CYTOTOXIC LYMPHOCYTES IN HSV-1 CORNEAL LESIONSR01EY005945 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HENDRICKS, ROBERT L · 1986 to 2017
$8.3M
Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
Contribution of Sympathetic Nerves to Herpes Stromal KeratitisR01EY026891 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ANTHONY J ST LEGER · 2017 to 2026
$4.7M
Mechanisms of PD-1 and Tim-3 crosstalk in tumor-infiltrating lymphocytesR01CA206517 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Robert L. Ferris, Lawrence P. Kane · 2016 to 2026
$4.6M
Interdisciplinary Visual Sciences (IVS) Traininig ProgramT32EY017271 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Marlene Behrmann, Paul R. Kinchington · 2008 to 2026
$3.6M
Gene Expression in HSV-1 Latency After Corneal InfectionR01EY015291 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINCHINGTON, PAUL R. · 2004 to 2013
$2.9M
Regulation of T cell activation and exhaustion by Tim-3R01AI138504 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KANE, LAWRENCE P. · 2018 to 2021
$1.7M
Microbiome-dependent modulation of ocular immunity and the implications for infectious R00EY025761 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ST LEGER, ANTHONY J · 2018 to 2020
$862k
NCI NIH HHS R01 CA206517NEI NIH HHS P30 EY008098NEI NIH HHS R00 EY025761NEI NIH HHS R01 EY005945NEI NIH HHS R01 EY015291NEI NIH HHS R01 EY026891NEI NIH HHS T32 EY017271NIAID NIH HHS R01 AI138504NIAID NIH HHS T32 AI049820
6 · The paper itself

Abstract

Herpes simplex virus 1 (HSV-1) causes a lifelong infection of neurons that innervate barrier sites like the skin and mucosal surfaces like the eye. After primary infection of the cornea, the virus enters latency within the trigeminal ganglion (TG), from which it can reactivate throughout the life of the host. Viral latency is maintained, in part, by virus-specific CD8

Indexed as

Lymphocyte ActivationTrigeminal GanglionAnimalsBiomarkersCD8-Positive T-LymphocytesEpitopes, T-LymphocyteFemaleGene Expression RegulationHepatitis A Virus Cellular Receptor 2Herpesvirus 1, HumanMiceProgrammed Cell Death 1 ReceptorVirus LatencyBiomarkersEpitopes, T-LymphocyteHavcr2 protein, mouseHepatitis A Virus Cellular Receptor 2Pdcd1 protein, mouseProgrammed Cell Death 1 ReceptorCD8+ T cellscheckpoint moleculeHSV-1immunologyvirology

Identifiers

PMID31645447
PMCPMC6955272
OpenAlexW2980894837

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.