Evidence map›Paper›PMID 31645420›Full record

ArticleG3 (Bethesda, Md.)2019

Network-Based Functional Prediction Augments Genetic Association To Predict Candidate Genes for Histamine Hypersensitivity in Mice.

Anna L Tyler, Abbas Raza, Dimitry N Krementsov, Laure K Case, Rui Huang, Runlin Z Ma, Elizabeth P Blankenhorn, Cory Teuscher, J Matthew Mahoney

Open access · goldAbstract read
In one paragraph

Article in G3 (Bethesda, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Systemic capillary leak syndrome.Nature reviews. Disease primers · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Anna L TylerThe Jackson Laboratory, 600 Main St. Bar Harbor, ME, 04609.ORCID 0000-0001-8371-2377
Abbas RazaDepartment of Medicine.
Dimitry N KrementsovDepartment of Biomedical and Health Sciences, John.M.Mahoney@uvm.edu.ORCID 0000-0003-2709-7466
Laure K CaseThe Jackson Laboratory, 600 Main St. Bar Harbor, ME, 04609.
Rui HuangSchool of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China, and.
Runlin Z MaSchool of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China, and.
Elizabeth P BlankenhornDepartment of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA.
Cory TeuscherDepartment of Medicine, John.M.Mahoney@uvm.edu.ORCID 0000-0002-9236-8843
J Matthew MahoneyDepartment of Neurological Sciences, John.M.Mahoney@uvm.edu.ORCID 0000-0003-1425-5939
Jackson Laboratory · USUniversity of Chinese Academy of Sciences · CNDrexel University · USUniversity of Vermont · US

Funding

Interactions Between Host Genetics and the Gut Microbiome in CNS AutoimmunityR01NS097596 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2017 to 2021
$1.7M
Next generation systems analysis of pathogenetic mechanisms underlying CNS autoimmunityR21AI145306 · NIAID · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI KREMENTSOV, DIMITRY N · 2019 to 2020
$429k
Inferring Molecular Mechanisms of Complex Disease by Integrating Patterns of Epistasis with Functional Genomic NetworksR21LM012615 · NLM · JACKSON LABORATORY · PI MAHONEY, JOHN MATTHEW, TYLER, ANNA L. · 2018 to 2019
$423k
NIAID NIH HHS R21 AI145306NINDS NIH HHS R01 NS097596NLM NIH HHS R21 LM012615
6 · The paper itself

Abstract

Genetic mapping is a primary tool of genetics in model organisms; however, many quantitative trait loci (QTL) contain tens or hundreds of positional candidate genes. Prioritizing these genes for validation is often

Indexed as

Chromosome MappingPolymorphism, Single NucleotideQuantitative Trait LociAnimalsHistamineHypersensitivityMiceHistamineClarkson’s DiseaseGene prioritizationhistamine hypersensitivitymachine learningquantitative trait locus

Identifiers

PMID31645420
PMCPMC6893195
OpenAlexW2981456232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.