Evidence map›Paper›PMID 31645370›Full record

ArticleJournal of lipid research2020

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition.

Akira Honda, Teruo Miyazaki, Junichi Iwamoto, Takeshi Hirayama, Yukio Morishita, Tadakuni Monma, Hajime Ueda, Seiya Mizuno, Fumihiro Sugiyama, Satoru Takahashi and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of lipid research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed, 3 pooled it
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed, 3 syntheses or guidelines pooled it, 206 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Role of Bile Acid Receptors in Non-Infectious Diarrhea: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  6. Article
  7. Article
  8. Gastrodin Ameliorates Type II Diabetes Through the YY1-FXR-Bile Acid Axis.International journal of molecular sciences · 2026
    Article
  9. Farnesoid x Receptor Deficiency Promotes Hepatocytic Injury in Cyp2c70-Deficient Mice With a Human-Like Bile Acid Composition.Liver international : official journal of the International Association for the Study of the Liver · 2026
    Article
  10. Article
  11. Article
  12. Cholestasis in Alcohol-Associated Liver Disease.The American journal of pathology · 2026
    Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Gly-βMCA modulates bile acid metabolism to reduce hepatobiliary injury inAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  19. Article
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Akira HondaJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan; Department of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan. Electronic address: akirahonda-gi@umin.ac.jp.
Teruo MiyazakiJoint Research Center, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Junichi IwamotoDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Takeshi HirayamaDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Yukio MorishitaDiagnostic Pathology Division, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Tadakuni MonmaDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Hajime UedaDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Seiya MizunoLaboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Fumihiro SugiyamaLaboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Satoru TakahashiLaboratory Animal Resource Center, University of Tsukuba, Ibaraki, Japan.
Tadashi IkegamiDepartment of Gastroenterology and Hepatology, Tokyo Medical University Ibaraki Medical Center, Ibaraki, Japan.
Tokyo Medical University Ibaraki Medical Center · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse

Indexed as

Disease Models, AnimalAnimalsAryl Hydrocarbon HydroxylasesBile Acids and SaltsChenodeoxycholic AcidCytochrome P-450 Enzyme SystemFemaleHydrophobic and Hydrophilic InteractionsMaleMiceMice, Inbred C57BLMice, KnockoutMolecular StructureRatsRats, Sprague-DawleySteroid HydroxylasesAryl Hydrocarbon HydroxylasesBile Acids and SaltsChenodeoxycholic Acidcytochrome P-450 2C70, mouseCytochrome P-450 Enzyme Systemsteroid hormone 7-alpha-hydroxylaseSteroid Hydroxylases7α-hydroxy-4-cholesten-3-one 12α-hydroxylasecholesterol 7α-hydroxylaseCRISPR-Cas9CYP2A12CYP2C70cytochrome P450cytokinesfarnesoid X receptorknockout mousepregnane X receptor

Identifiers

PMID31645370
PMCPMC6939601
OpenAlexW2981636929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.