Evidence map›Paper›PMID 31645360›Full record

ArticleGenetics2019

Tel1 Activation by the MRX Complex Is Sufficient for Telomere Length Regulation but Not for the DNA Damage Response in

Rebecca Keener, Carla J Connelly, Carol W Greider

Open access · bronzeAbstract read
In one paragraph

Article in Genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Rebecca KeenerDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.ORCID 0000-0001-9031-6866
Carla J ConnellyDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.ORCID 0000-0002-9218-5609
Carol W GreiderDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 cgreider@jhmi.edu.ORCID 0000-0002-5494-8126
Johns Hopkins Medicine · USJohns Hopkins University · US

Funding

BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

Previous models suggested that regulation of telomere length in

Indexed as

DNA DamageAmino Acid MotifsIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesPhosphorylationProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsSignal TransductionTelomereTelomere HomeostasisIntracellular Signaling Peptides and ProteinsMultiprotein ComplexesProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinsTEL1 protein, S cerevisiaeDNA damage responseepistasisMRX complexTel1telomere

Identifiers

PMID31645360
PMCPMC6893380
OpenAlexW2981632043

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.