Evidence map›Paper›PMID 31645342›Full record

Observational studyCancer prevention research (Philadelphia, Pa.)2019

Using Digital Pathology to Understand Epithelial Characteristics of Benign Breast Disease among Women Undergoing Diagnostic Image-Guided Breast Biopsy.

Maeve Mullooly, Samantha Puvanesarajah, Shaoqi Fan, Ruth M Pfeiffer, Linnea T Olsson, Manila Hada, Erin L Kirk, Pamela M Vacek, Donald L Weaver, John Shepherd and 9 more

Open access · bronzeAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Cancer prevention research (Philadelphia, Pa.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 79% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Maeve Mullooly *Division of Population Health Science, Royal College of Surgeons in Ireland, Dublin, Ireland. maevemullooly@rcsi.ie.
Samantha Puvanesarajah *Behavioral and Epidemiology Research Program, American Cancer Society, Atlanta, Georgia.ORCID 0000-0001-8476-8081
Shaoqi FanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Ruth M PfeifferDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.ORCID 0000-0001-7791-2698
Linnea T OlssonDepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-2786-5966
Manila HadaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Erin L KirkDepartment of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Pamela M VacekThe University of Vermont and The University of Vermont Cancer Center, Burlington, Vermont.
Donald L WeaverThe University of Vermont and The University of Vermont Cancer Center, Burlington, Vermont.
John ShepherdUniversity of Hawaii Cancer Center, Honolulu, Hawaii.
Amir MahmoudzadehUniversity of California, San Francisco, San Francisco, California.ORCID 0000-0003-4322-5325
Jeff WangDepartment of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan.
Serghei MalkovUniversity of California, San Francisco, San Francisco, California.
Jason M JohnsonThe University of Texas MD Anderson Cancer Center, Houston, Texas.
Stephen M HewittCenter for Cancer Research, National Cancer Institute, Bethesda, Maryland.
Sally D HerschornThe University of Vermont and The University of Vermont Cancer Center, Burlington, Vermont.ORCID 0000-0002-9193-6490
Mark E Sherman *Mayo Clinic, Jacksonville, Florida.
Melissa A Troester *Department of Epidemiology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Gretchen L Gierach *Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
National Cancer Institute · USUniversity of North Carolina at Chapel Hill · USUniversity of Vermont · USUniversity of California, San Francisco · USAmerican Cancer Society · USCancer Center of Hawaii · USHokkaido University of Science · JPMayo Clinic in Florida · USRoyal College of Surgeons in Ireland · IEThe University of Texas MD Anderson Cancer Center · US

Funding

Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
Pregnancy, Obesogenic Environments, and Basal-like Breast CancerU01ES019472 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TROESTER, MELISSA A. · 2010 to 2014
$2.3M
Biology of Race and Progression Associated Breast Tumor Gene ExpressionU01CA179715 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEROU, CHARLES M, TROESTER, MELISSA A. · 2014 to 2018
$1.6M
Intramural NIH HHS ZIA CP010126NCI NIH HHS U01 CA179715NIEHS NIH HHS U01 ES019472
6 · The paper itself

Abstract

Delayed terminal duct lobular unit (TDLU) involution is associated with elevated mammographic breast density (MD). Both are independent breast cancer risk factors among women with benign breast disease (BBD). Prior digital analyses of normal breast tissues revealed that epithelial nuclear density (END) and TDLU involution are inversely correlated. Accordingly, we examined associations of END, TDLU involution, and MD in BBD clinical biopsies. This study included digitized images of 262 representative image-guided hematoxylin and eosin-stained biopsies from 224 women diagnosed with BBD, enrolled within the cross-sectional BREAST-Stamp project that were visually assessed for TDLU involution (TDLU count/100 mm

Indexed as

Image Interpretation, Computer-AssistedAbsorptiometry, PhotonAdultAgedAge FactorsAlgorithmsBreastBreast DensityBreast NeoplasmsCross-Sectional StudiesEpitheliumFemaleFibrocystic Breast DiseaseHumansImage-Guided BiopsyLogistic Models

Identifiers

PMID31645342
PMCPMC7357278
OpenAlexW2981419003

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.