ArticleEmerging microbes & infections2019
Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels.
Article in Emerging microbes & infections, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Designing Sandwich ELISA with Broadly Reactive Anti-Nucleocapsid Monoclonal Antibodies to Detect Bat-Borne Merbecoviruses.Viruses · 2025Article
- Assessment and sero-diagnosis for coronaviruses with risk of human spillover.Emerging microbes & infections · 2023Article
- Meta-analysis of seroprevalence and zoonotic infections of Middle East respiratory syndrome coronavirus (MERS-CoV): A one-health perspective.One health (Amsterdam, Netherlands) · 2022Article
- Analyzing the roles of some species of arthropods in the transmission of the Middle East respiratory syndrome coronavirus.Veterinary medicine and science · 2022Article
- Functional reconstitution of the MERS CoV receptor binding motif.Molecular immunology · 2022Article
- Knowledge, attitudes, and practices on camel respiratory diseases and conditions in Garissa and Isiolo, Kenya.Frontiers in veterinary science · 2022Article
- Viromes and surveys of RNA viruses in camel-derived ticks revealing transmission patterns of novel tick-borne viral pathogens in Kenya.Emerging microbes & infections · 2021Article
- Surface‒Aerosol Stability and Pathogenicity of Diverse Middle East Respiratory Syndrome Coronavirus Strains, 2012‒2018.Emerging infectious diseases · 2021Article
- Surface-aerosol stability and pathogenicity of diverse MERS-CoV strains from 2012 - 2018.bioRxiv : the preprint server for biology · 2021Article
- Comparative analysis of the genome structure and organization of the Middle East respiratory syndrome coronavirus (MERS-CoV) 2012 to 2019 revealing evidence for virus strain barcoding, zoonotic transmission, and selection pressure.Reviews in medical virology · 2021Review
- Evolution, Ecology, and Zoonotic Transmission of Betacoronaviruses: A Review.Frontiers in veterinary science · 2021Review
- Mass Spectrometry and Structural Biology Techniques in the Studies on the Coronavirus-Receptor Interaction.Molecules (Basel, Switzerland) · 2020Review
- Review
- The importance of naturally attenuated SARS-CoV-2in the fight against COVID-19.Environmental microbiology · 2020Article
- Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing.mSphere · 2020Article
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dromedary camels are important reservoir hosts of various coronaviruses, including Middle East respiratory syndrome coronavirus (MERS-CoV) that cause human infections. CoV genomes regularly undergo recombination during infection as observed in bat SARS-related CoVs. Here we report for the first time that only a small proportion of MERS-CoV receptor-binding domain positive (RBD) of spike protein positive camel sera in Kenya were also seropositive to MERS-CoV nucleocapsid (NP). In contrast, many of them contain antibodies against bat HKU8-related (HKU8r)-CoVs. Among 584 camel samples that were positive against MERS-CoV RBD, we found only 0.48 (8.22%) samples were also positive for NP. Furthermore, we found bat HKU8r-CoV NP antibody in 73 (12.5%) of the MERS-CoV RBD positive and NP negative samples, yet found only 3 (0.43%) of the HKU8r-CoV S1 antibody in the same samples. These findings may indicate co-infection with MERS-CoV and a HKU8r-CoV in camels. It may also raise the possibility of the circulation of a recombinant coronavirus virus with the spike of MERS-CoV and the NP of a HKU8r-CoV in Kenya. We failed to find molecular evidence of an HKU8r-CoV or a putative recombinant virus. Our findings should alert other investigators to look for molecular evidence of HKU8r-CoV or recombinants.
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