Evidence map›Paper›PMID 31645154›Full record

ArticleThe journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians2021

Evaluating the impact of a standardized induction protocol to reduce adverse perinatal outcomes: a prospective cohort study.

Lisa D Levine, Katheryne L Downes, Rebecca F Hamm, Sindhu K Srinivas

Registry-linked trialAbstract read
In one paragraph

Article in The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07006896 (Labor Induction After Cesarean), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07006896 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Labor Induction After Cesarean: A Randomized Trial Of Cervical Balloon With or Without Oxytocin

TypeinterventionalSponsorUniversity of PennsylvaniaRan2025 to 2027Enrolled100ConditionsLabor Induction, Cesarean DeliveryArmsFoley balloon, Oxytocin
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Trial
  2. Cardiovascular-Related Maternal Mortality.Obstetrics and gynecology · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Identifying the effective components of a standardized labor induction protocol: secondary analysis of a randomized, controlled trial.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lisa D LevineMaternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Katheryne L DownesFoundation for Orthopedic Research and Education, Tampa, FL, USA.
Rebecca F HammMaternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Sindhu K SrinivasMaternal and Child Health Research Center, Department of Obstetrics & Gynecology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Funding

WOMENS REPRODUCTIVE HEALTH RESEARCH CAREER DEVELOPMENTK12HD001265 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Howell · 1998 to 2026
$7.5M
NICHD NIH HHS K12 HD001265
6 · The paper itself

Abstract

objectiveOur objective was to evaluate the impact of a standardized induction protocol on reducing maternal and neonatal morbidity in women undergoing an induction with an unfavorable cervix. STUDY

designWe performed a prospective cohort study of women undergoing an induction from May 2013 to June 2015. Women who were ≥18 years, ≥37 weeks with intact membranes and an unfavorable cervix (Bishop score of ≤6 and cervical dilation ≤2 cm) with no prior cesarean were included. We compared the following outcomes between women managed with the labor protocol versus women in an observation group, managed at the discretion of the provider: Labor length, cesarean delivery, maternal and neonatal morbidity, and neonatal intensive care unit admission for >48 hours. Multivariable models incorporated confounders specific to each outcome.

results855 women were included (491: labor protocol group; 364: observational group). Women in the labor protocol group had a shorter time to delivery (15.7 hours vs. 18.0 hours,

conclusionUtilization of a standardized induction protocol was associated with a significant reduction in neonatal morbidity without increasing the risk of cesarean or maternal morbidity.

Indexed as

Labor, InducedLabor, ObstetricCesarean SectionFemaleHumansInfant, NewbornLabor Stage, FirstPregnancyProspective StudiesActive managementcesarean deliveryinduction of labor protocolmaternal morbidityneonatal morbidity

Identifiers

PMID31645154
PMCPMC7180115

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.