ArticleJournal of the neurological sciences2019
Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke.
Article in Journal of the neurological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Association between the Fibrosis-4 index and stroke and related outcomes: a meta-analysis.Frontiers in neurology · 2026Pooled it
- Association Between Non-alcoholic Fatty Liver Disease and Risk of Stroke: A Systematic Review and Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Review
- The association between liver disease and stroke risk: A cross-sectional study with machine learning in a large-scale Chinese cohort.International journal of cardiology. Cardiovascular risk and prevention · 2026Article
- Emerging Therapeutic Perspectives in Obese Patients with MASLD Leading to Compensated Advanced Chronic Liver Disease.Biomolecules · 2026Review
- Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study.Journal of the American Heart Association · 2025Article
- Artificial Intelligence and Image Analysis-Assisted Diagnosis for Fibrosis Stage of Metabolic Dysfunction-Associated Steatotic Liver Disease Using Ultrasonography: A Pilot Study.Diagnostics (Basel, Switzerland) · 2024Article
- The association between liver fibrosis score and incident dementia: A nationwide retrospective cohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Metabolic Dysfunction-Associated Steatohepatitis and Progression to Hepatocellular Carcinoma: A Literature Review.Cancers · 2024Review
- The clinical value of fibrosis indices for predicting the hemorrhagic transformation in patients with acute ischemic stroke after intravenous thrombolysis.Frontiers in aging neuroscience · 2024Article
- Review
- Liver fibrosis-4 score predicts outcome of patients with ischemic stroke undergoing intravenous thrombolysis.Frontiers in neurology · 2023Article
- Association between liver fibrosis and incident dementia in the UK Biobank study.European journal of neurology · 2022Article
- Hepatic Fibrosis Is a Risk Factor for Greater Severity and Worse Outcome of Acute Ischemic Stroke.Journal of clinical medicine · 2022Article
- Liver Fibrosis-4 index indicates atrial fibrillation in acute ischemic stroke.European journal of neurology · 2022Article
- Article
- Pathophysiological Molecular Mechanisms of Obesity: A Link between MAFLD and NASH with Cardiovascular Diseases.International journal of molecular sciences · 2021Review
- Ultrasonographic grayscale findings related to fibrosis in patients with non-alcoholic fatty liver disease: comparison with transient elastography and Fib-4 index.Journal of medical ultrasonics (2001) · 2021Article
- Non-invasive markers of liver fibrosis and outcome in large vessel occlusion stroke.Therapeutic advances in neurological disorders · 2021Article
- The Association between Nonalcoholic Fatty Liver Disease and Stroke: Results from the Korean Genome and Epidemiology Study (KoGES).International journal of environmental research and public health · 2020Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is an increasing appreciation of the cardiovascular implications of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis). However, data regarding stroke risk are limited. We sought to investigate whether NAFLD-fibrosis is associated with stroke in addition to heart disease.
methodsWe performed a cross-sectional study using data from the United States National Health and Nutrition Examination Survey (2005-2014). After excluding participants with competing causes of liver disease, the Fibrosis-4 score (FIB-4) and NAFLD Fibrosis Score (NFS) were calculated. First, we used a composite measure to classify participants: NAFLD-fibrosis was defined as having at least one score above its validated cut-off. Second, we also used the FIB-4 and NFS scores individually. The key outcome was prevalent stroke, and we also evaluated heart disease; both were self-reported. Multivariable logistic regression assessed the association between NAFLD-fibrosis and these outcomes while adjusting for demographic variables and cardiovascular risk factors.
resultsWe identified 1653 participants with NAFLD-fibrosis from a sample of 27,040 participants. In total, 753 had prior stroke. An association between NAFLD-fibrosis and stroke was seen when using the FIB-4 score (OR 1.87, 95% CI 1.00-3.50) but not the NFS (OR 1.31, 95% CI 0.92-1.87). NAFLD-fibrosis was associated with heart disease (OR 1.46, 95% CI 1.06-2.01) using the composite measure and both scores individually.
conclusionsNAFLD-fibrosis may be associated with stroke in addition to heart disease, with differences depending on the measure used to define NAFLD-fibrosis.
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