ArticleCell reports2019
Combinatorial Pharyngeal Taste Coding for Feeding Avoidance in Adult Drosophila.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Convergent olfactory circuits for courtship in Drosophila revealed by the circuit-tracing tool ds-Tango.Current biology : CB · 2026Article
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- Modulation of attractive salt taste iniScience · 2026Article
- Activity and State-Dependent Modulation of Salt Taste Behavior Via Pharyngeal Neurons inNeuroscience insights · 2026Article
- Intelligent data governance and quality control for chest Bi syndrome/coronary heart disease across the prevention-treatment-rehabilitation continuum: integrating a standardized framework, adversarially-optimized trigger engine, and domain-adaptive AI.Frontiers in medical technology · 2026Article
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- Connectomic mapping of pharyngeal and gut sensory circuits in adultbioRxiv : the preprint server for biology · 2025Article
- Gal4 drivers of the geosmin receptor Or56a exhibit ectopic expression in the labral sense organ of Drosophila.Scientific reports · 2025Article
- Connectomics Reveals a Feed-Forward Swallowing Circuit Driving Protein Appetite.bioRxiv : the preprint server for biology · 2025Article
- Bitter Sensing ProtectsThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Transsynaptic labeling and transcriptional control of zebrafish neural circuits.Nature neuroscience · 2025Article
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- The pharyngeal taste organ of a blood-feeding insect functions in food recognition.BMC biology · 2024Article
- Evolution of fatty acid taste in drosophilids.Cell reports · 2023Article
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- An inhibitory mechanism for suppressing high salt intake in Drosophila.Chemical senses · 2023Article
- Meeting a threat of the Anthropocene: Taste avoidance of metal ions byProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Protocol for binary food choice assays usingSTAR protocols · 2022Article
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Authors and funding
5 authors.
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Abstract
Taste drives appropriate food preference and intake. In Drosophila, taste neurons are housed in both external and internal organs, but the latter have been relatively underexplored. Here, we report that Poxn mutants with a minimal taste system of pharyngeal neurons can avoid many aversive tastants, including bitter compounds, acid, and salt, suggesting that pharyngeal taste is sufficient for rejecting intake of aversive compounds. Optogenetic activation of selected pharyngeal bitter neurons during feeding events elicits changes in feeding parameters that can suppress intake. Functional dissection experiments indicate that multiple classes of pharyngeal neurons are involved in achieving behavioral avoidance, by virtue of being inhibited or activated by aversive tastants. Tracing second-order pharyngeal circuits reveals two main relay centers for processing pharyngeal taste inputs. Together, our results suggest that the pharynx can control the ingestion of harmful compounds by integrating taste input from different classes of pharyngeal neurons.
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