ArticleeLife2019
Electric field causes volumetric changes in the human brain.
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Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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42citing papers in PubMed, 2 pooled it
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of electroconvulsive therapy on cortical thickness in depression: a systematic review.Acta neuropsychiatrica · 2024Pooled it
- Meta-analytic Evidence for Volume Increases in the Medial Temporal Lobe After Electroconvulsive Therapy.Biological psychiatry · 2021Pooled it
- Brain morphometry, stimulation charge, and seizure duration in electroconvulsive therapy.Molecular psychiatry · 2026Article
- Clinical and biological markers of electroconvulsive therapy effectiveness: a narrative review.Translational psychiatry · 2026Review
- Computational Models of High-Definition Electroconvulsive Therapy for Focal or Multitargeting Treatment.The journal of ECT · 2025Article
- Effects of electroconvulsive therapy on hippocampal longitudinal axis and its association with cognitive side effects.Communications medicine · 2025Article
- Electroconvulsive therapy-specific volume changes in nuclei of the amygdala and their relationship to long-term anxiety improvement in depression.Molecular psychiatry · 2025Observational
- The relationship between electric field strength induced by electroconvulsive therapy and cognitive and antidepressant outcomes.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans.Nature communications · 2025Article
- Electroconvulsive therapy and cognitive performance from the Global ECT MRI Research Collaboration.Journal of psychiatric research · 2024Article
- Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression.Molecular psychiatry · 2024Article
- Electroconvulsive therapy modulates loudness dependence of auditory evoked potentials: a pilot MEG study.Frontiers in psychiatry · 2024Article
- How electroconvulsive therapy works in the treatment of depression: is it the seizure, the electricity, or both?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Neurobiological mechanisms of ECT and TMS treatment in depression: study protocol of a multimodal magnetic resonance investigation.BMC psychiatry · 2023Article
- The Fifth Bioelectronic Medicine Summit: today's tools, tomorrow's therapies.Bioelectronic medicine · 2023Article
- Baseline levels of miR-223-3p correlate with the effectiveness of electroconvulsive therapy in patients with major depression.Translational psychiatry · 2023Article
- Electric Field, Ictal Theta Power, and Clinical Outcomes in Electroconvulsive Therapy.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Electroconvulsive therapy-induced volumetric brain changes converge on a common causal circuit in depression.Research square · 2023Article
- Clinical Improvement in Depression and Cognitive Deficit Following Electroconvulsive Therapy.Diagnostics (Basel, Switzerland) · 2023Review
- Cerebro-cerebellar functional neuroplasticity mediates the effect of electric field on electroconvulsive therapy outcomes.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
30 authors.
Miklos ArgyelanDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States.ORCID 0000-0002-7254-1776
Leif OltedalDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Zhi-De DengExperimental Therapeutics and Pathophysiology Branch, National Institute of Mental Health, Bethesda, United States.
Benjamin WadeDepartment of Neurology, Ahmanson-Lovelace Brain Mapping Center, University of California, Los Angeles, Los Angeles, United States.
Marom BiksonDepartment of Biomedical Engineering, The City College of the City University of New York, New York, United States.
Andrea JoanlanneDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States.
Sohag SanghaniDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States.
Hauke BartschDepartment of Radiology, Haukeland University Hospital, Mohn Medical Imaging and Visualization Centre, Bergen, Norway.
Marta CanoDepartment of Psychiatry, Bellvitge University Hospital-IDIBELL, Barcelona, Spain.ORCID 0000-0003-0675-9483
Anders M DaleCenter for Multimodal Imaging and Genetics, University of California, San Diego, San Diego, United States.
Udo DannlowskiDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Annemiek DolsDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands.
Verena EnnekingDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Randall EspinozaDepartment of Neurology, University of California, Los Angeles, Los Angeles, United States.
Ute KesslerDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Katherine L NarrDepartment of Neurology, University of California, Los Angeles, Los Angeles, United States.
Ketil J OedegaardDepartment of Clinical Medicine, University of Bergen, Bergen, Norway.
Mardien L OudegaDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands.
Ronny RedlichDepartment of Psychiatry and Psychotherapy, University of Muenster, Muenster, Germany.
Max L StekDepartment of Psychiatry, Amsterdam UMC, location VUmc, GGZinGeest, Old Age Psychiatry, Amsterdam Neuroscience, Amsterdam, Netherlands.
Akihiro TakamiyaDepartment of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Louise EmsellDepartment of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, Belgium.
Filip BouckaertDepartment of Geriatric Psychiatry, University Psychiatric Center, KU Leuven, Leuven, Belgium.
Pascal SienaertAcademic center for ECT and Neurostimulation (AcCENT), University Psychiatric Center, KU Leuven, Kortenberg, Belgium.
Jesus PujolCIBERSAM, Carlos III Health Institute, Barcelona, Spain.
Indira TendolkarDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands.
Philip van EijndhovenDepartment of Psychiatry, Radboud University Medical Center, Nijmegen, Netherlands.
Georgios PetridesDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States.
Anil K MalhotraDepartment of Psychiatry, The Zucker Hillside Hospital, Glen Oaks, United States.
Christopher AbbottDepartment of Psychiatry, University of New Mexico School of Medicine, Albuquerque, United States.
Funding
Perturbation of the treatment resistant depression connectome by fast-acting therapiesU01MH110008 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2016 to 2019
$5.5MImaging biomarkers of ECT response in major depressive disorderR01MH092301 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ESPINOZA, RANDALL, NARR, KATHERINE L · 2011 to 2015
$4.0MECT current amplitude and medial temporal lobe engagementU01MH111826 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2017 to 2019
$1.5MBiomarkers of fast acting therapies in major depressionK24MH102743 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NARR, KATHERINE L · 2014 to 2018
$889kNeural Biomarkers of ECT Response in SchizophreniaK23MH120504 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ARGYELAN, MIKLOS · 2020 to 2023
$781kECT current amplitude and medial temporal lobe engagementR01MH111826 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI ABBOTT, CHRISTOPHER C · 2016 to 2016
$522kElectrical Field and Neuroimaging Based Prediction of ECT Induced Clinical and Cognitive EffectsR21MH119616 · NIMH · FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH · PI ARGYELAN, MIKLOS · 2019 to 2020
$454kDeutsche Forschungsgemeinschaft DA1151/5-1Deutsche Forschungsgemeinschaft DA1151/5-2Deutsche Forschungsgemeinschaft DFG FOR2107Deutsche Forschungsgemeinschaft DFG FOR2107 DA1151/5-1 and DA1151/5-2Deutsche Forschungsgemeinschaft Project C09Deutsche Forschungsgemeinschaft Projects C09 and Z02Deutsche Forschungsgemeinschaft Project Z02Deutsche Forschungsgemeinschaft SFB-TRR58Innovative Medical Research RE111604Innovative Medical Research RE111604 and RE111722Innovative Medical Research RE111722NIMH NIH HHS K23 MH120504NIMH NIH HHS K24 MH102743NIMH NIH HHS MH092301NIMH NIH HHS MH102743NIMH NIH HHS MH110008NIMH NIH HHS MH111826NIMH NIH HHS MH119616NIMH NIH HHS R01 MH092301NIMH NIH HHS R01 MH111826NIMH NIH HHS R21 MH119616NIMH NIH HHS U01 MH110008NIMH NIH HHS U01 MH111826NIMH NIH HHS ZIAMH00295University of Bergen Fulbright ProgramWestern Norway Regional Health Authority 911986Western Norway Regional Health Authority 912238
Abstract
Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
Indexed as
AdultAgedAmygdalaAntidepressive AgentsBrain MappingDepressionElectroconvulsive TherapyElectromagnetic RadiationFemaleHippocampusHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeTemporal LobeAntidepressive AgentsdepressionECTelectric field modelinghumanhuman biologymedicineneuroimagingvolume change
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