ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020
The impact of chemotherapy on cognitive function: a multicentre prospective cohort study in testicular cancer.
Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Demonstration of chemotherapeutic-mediated changes in meningeal lymphatics in vitro, ex vivo, and in vivo.Communications biology · 2025Article
- A study of subjective memory impairment in long-term testicular cancer survivors.British journal of cancer · 2025Article
- Association between low total serum testosterone and body mass index in Australian survivors of testicular cancer: a retrospective analysis.Basic and clinical andrology · 2024Article
- Cognitive function in long-term testicular cancer survivors: impact of modifiable factors.JNCI cancer spectrum · 2024Article
- A scoping review of cognitive assessment tools and domains for chemotherapy-induced cognitive impairments in cancer survivors.Frontiers in human neuroscience · 2023Article
- Exploration of motivation to participate in a study of cancer-related cognitive impairment among patients with newly diagnosed aggressive lymphoma: a qualitative sub-study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Article
- Effect of Respiratory Training Combined with Core Muscle Training on the Overall Motor Function and Activities of Daily Living of Patients with Early and Midterm Stroke.Journal of healthcare engineering · 2022Article
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.Archives of toxicology · 2022Review
- Brain morphological alterations and their correlation to tumor differentiation and duration in patients with lung cancer after platinum chemotherapy.Frontiers in oncology · 2022Article
- Cognitive Impairment in Long-Term Survivors of Testicular Cancer More Than 20 Years after Treatment.Cancers · 2021Article
- An Updated Systematic Review of Quantitative Studies Assessing Anxiety, Depression, Fear of Cancer Recurrence or Psychological Distress in Testicular Cancer Survivors.Cancer management and research · 2021Review
- Long-Term Cognitive Dysfunction in Cancer Survivors.Frontiers in molecular biosciences · 2021Review
- Patient-Reported Outcomes Associated with Treatments for Testicular Cancer: A Systematic Review.Patient related outcome measures · 2021Review
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
purposeThe causal link between chemotherapy and cognitive impairment is unclear. We studied testicular cancer patients' objective and subjective cognitive function longitudinally, comparing a surgery group with a surgery + chemotherapy group, addressing prior methodological issues using a computerized test to limit assessment issues, and controlling for confounding variables.
methodsProspectively, of 145 patients from 16 centres with sufficient data, n = 61 receiving surgery + chemotherapy (etoposide and cisplatin ± bleomycin, BEP/EP; or single agent carboplatin) were compared to n = 41 receiving surgery alone. CogHealth assessed six objective cognitive tasks. The Cognitive Failures Questionnaire assessed self-perceived cognitive dysfunction. The Functional Assessment of Chronic Illness Therapy-Fatigue and the Hospital Anxiety and Depression Scale assessed psychological influences. Linear mixed models compared changes from baseline (< 6 months post-surgery/pre-chemotherapy) to follow-up (12-18 months post-baseline), controlling covariates.
resultsThere were no significant interaction effects for five objective cognitive function tasks suggesting that changes over time were not due to group membership. However, psychomotor function (controlling for age) and physical well-being were significantly worse for the chemotherapy versus the surgery group at baseline, with groups converging by follow-up. Groups showed no differences in subjective cognitive dysfunction. The chemotherapy group showed higher anxiety, poorer functional well-being and worse fatigue compared to the surgery-only group at baseline, but not by follow-up. For both groups, emotional well-being, functional well-being and anxiety significantly improved over time.
conclusionNo substantive differences in objective or subjective cognitive dysfunction in either group persisted 12-18 months post-baseline. Patients undergoing chemotherapy for testicular cancer differ from findings in breast cancer populations.
trial registrationClinicalTrials.gov Identifier: ACTRN12609000545268.
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