Evidence map›Paper›PMID 31642509›Full record

ArticleNeurosurgery2020

Acquired Personality Disturbances After Meningioma Resection Are Strongly Associated With Impaired Quality of Life.

Joseph Barrash, Taylor J Abel, Katrina L Okerstrom-Jezewski, Mario Zanaty, Joel E Bruss, Kenneth Manzel, Matthew Howard, Daniel Tranel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Lesions in different prefrontal sectors are associated with different types of acquired personality disturbances.Cortex; a journal devoted to the study of the nervous system and behavior · 2022
    Observational
  5. Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joseph BarrashDepartment of Neurology, University of Iowa, Iowa City, Iowa.
Taylor J AbelDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania.
Katrina L Okerstrom-JezewskiDepartment of Neurology, University of Iowa, Iowa City, Iowa.
Mario ZanatyDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa.
Joel E BrussDepartment of Neurology, University of Iowa, Iowa City, Iowa.
Kenneth ManzelDepartment of Neurology, University of Iowa, Iowa City, Iowa.
Matthew HowardDepartment of Neurosurgery, University of Iowa, Iowa City, Iowa.
Daniel TranelDepartment of Neurology, University of Iowa, Iowa City, Iowa.
University of Iowa · USUniversity of Pittsburgh · US

Funding

The Neurobiology of Social Decision-Making: Social Inference and ContextP50MH094258 · NIMH · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI MOBBS, DEAN · 2012 to 2021
$18.6M
Electrophysiology of proper naming in the human left anterior temporal lobeF32NS087664 · NINDS · UNIVERSITY OF IOWA · PI ABEL, TAYLOR JOHN · 2014 to 2015
$123k
NIMH NIH HHS P50 MH094258NINDS NIH HHS F32 NS087664
6 · The paper itself

Abstract

backgroundSome patients experience long-term declines in quality of life following meningioma resection, but associated factors are not well understood.

objectiveTo investigate whether long-term declines in quality of life (specifically impaired adaptive functioning) after meningioma resection are associated with specific personality disturbances that often develop with lesions in ventromedial prefrontal cortex (vmPFC).

methodsWe studied 38 patients who underwent resection of meningioma, 18 of whom had vmPFC lesions and 20 with lesions elsewhere (non-vmPFC). A total of 30 personality characteristics were rated by spouse or family, and a neuropsychologist blindly rated adaptive functioning an average of 3.8 yr postresection. Relevant personality disturbance was defined by a priori process: the presence of "conjoint personality disturbance" required specific disturbances in at least 2 of 4 types of disturbance: executive disorders, disturbed social behavior, emotional dysregulation, and hypoemotionality.

resultsFourteen patients had impaired adaptive functioning: 12 had vmPFC lesions and 2 had non-vmPFC lesions. Fourteen patients had conjoint personality disturbance, and 12 of them had impaired adaptive functioning. By contrast, among the 24 patients who did not have conjoint personality disturbance, only 2 had impaired adaptive functioning. Mediation analysis showed that the association between vmPFC lesions and impaired adaptive functioning was mediated by the negative impact of acquired personality disturbance on adaptive functioning.

conclusionAnterior skull base meningiomas plus resection surgery may result in specific personality disturbances that are highly associated with impaired adaptive functioning at long-term follow-up. These patients may benefit from early counseling regarding potential personality changes and their implications for adaptive functioning.

Indexed as

Postoperative ComplicationsQuality of LifeAdultFemaleHumansMaleMeningeal NeoplasmsMeningiomaMiddle AgedNeurosurgical ProceduresPersonality DisordersBrain tumorFrontal lobeIowa Scales of Personality ChangePersonality changeVentromedial prefrontal cortex

Identifiers

PMID31642509
PMCPMC7360876
OpenAlexW2981384183

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.