ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2019
[Role of the Notch signaling pathway in children with tuberculosis].
Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 4 citations in OpenAlex.
- IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses.Journal of immunology research · 2021Observational
- CircAGFG1modulates autophagy and apoptosis of macrophages infected by Mycobacterium tuberculosis via the Notch signaling pathway.Annals of translational medicine · 2020Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
objectiveTo study the expression of molecules associated with the Notch signaling pathway in children with tuberculosis, as well as the role of this pathway in the pathogenesis of tuberculosis in children.
methodsA total of 62 children who were diagnosed with tuberculosis from June 2017 to December 2018 were enrolled as the case group, and 64 healthy children were enrolled as the healthy control group. Peripheral venous blood samples with a volume of 2 mL were collected, and quantitative real-time PCR was used to measure the mRNA expression levels of the molecules associated with the Notch signaling pathway (receptors Notch1-4, ligands Jagged1/2 and DLL1/3/4, and downstream target genes Hes1 and Hey1) in leukocytes.
resultsCompared with the healthy control group, the case group had significant increases in the mRNA expression levels of Notch1, Notch2, and DLL4 in leukocytes (P<0.05), while there were no significant differences in the mRNA expression levels of Notch3/4, Jagged1/2, DLL1/3, Hes1, and Hey1 between the two groups (P>0.05).
conclusionsThere are significant increases in the mRNA expression of Notch1/2 and DLL4 in children with tuberculosis, while there are no significant changes in the expression of downstream target genes, suggesting that the Notch signaling pathway, which is activated by the interaction between Notch1/2 and DLL4 after Mycobacterium tuberculosis infection, may play a role in childhood tuberculosis by acting on other target genes, and further studies are needed for clarification.
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Identifiers
31642436PMC7389733W3025067568What OpenQuestion holds
Registered trials
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