SynthesisJournal of the American Heart Association2019
Predictors of Late Mortality in D-Transposition of the Great Arteries After Atrial Switch Repair: Systematic Review and Meta-Analysis.
Synthesis in Journal of the American Heart Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Outcome of Pregnancy in Women With D-Transposition of the Great Arteries: A Systematic Review.Journal of the American Heart Association · 2022Pooled it
- Predictors of Late Mortality in D-Transposition of the Great Arteries After Atrial Switch Repair: Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- ASD Occluder Used to Close a Mustard Baffle Leak.JACC. Case reports · 2026Article
- Long-Term Results After Senning and Mustard Operations for d-Transposition of the Great Arteries: Atrial Switch Should Remain in Armamentarium.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2026Article
- Incidence and long-term outcomes of dextro-transposition of the great arteries (d-TGA) in the Kingdom of Bahrain.Frontiers in cardiovascular medicine · 2025Article
- Pathogenesis and Surgical Treatment of Dextro-Transposition of the Great Arteries (D-TGA): Part II.Journal of clinical medicine · 2024Review
- Clinical Factors Affecting Survival in Patients with Congenitally Corrected Transposition of the Great Arteries: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2024Article
- External Validation of a Risk Score Model for Predicting Major Clinical Events in Adults After Atrial Switch.Journal of the American Heart Association · 2024Article
- Atrial arrhythmia predicts late events and mortality in patients with D-transposition of the great arteries and atrial switch repair.International journal of cardiology. Congenital heart disease · 2024Article
- Outcomes of permanent pacemakers and implantable cardioverter-defibrillators in an adult congenital heart disease population.International journal of cardiology. Congenital heart disease · 2024Article
- Clinical Course of TGA After Arterial Switch Operation in the Current Era.JACC. Advances · 2024Article
- Longitudinal changes in systemic right ventricular remodeling in adult patients with transposition of the great vessels as assessed by cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Ventricular arrhythmia in congenital heart diseases with a systemic right ventricle.International journal of cardiology. Congenital heart disease · 2023Review
- Arrhythmias and Clinical Outcomes in a Swiss Multicenter Cohort of Patients With Dextro-Transposition of the Great Arteries and Atrial Switch.Journal of the American Heart Association · 2023Article
- Overview of Long-Term Outcome in Adults with Systemic Right Ventricle and Transposition of the Great Arteries: A Review.Diagnostics (Basel, Switzerland) · 2023Review
- Late outcomes in adults with atrial switch for transposition of the great arteries according to risk factor profile at 30 years of age.International journal of cardiology. Congenital heart disease · 2023Article
- Outcomes of malignancy in adults with congenital heart disease: a single center experience.Cardio-oncology (London, England) · 2022Article
- Single-stage arterial switch operation conversion with dextro-transposition of the great arteries and pulmonary arterial hypertension due to baffle leak after a Senning procedure.Journal of cardiology cases · 2022Article
- Cause-Specific Mortality in Patients During Long-Term Follow-Up After Atrial Switch for Transposition of the Great Arteries.Journal of the American Heart Association · 2022Article
- Deep Phenotypic Analysis for Transposition of the Great Arteries and Prognosis Implication.Journal of the American Heart Association · 2022Article
Corrections and comments
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Existing data on predictors of late mortality and prevention of sudden cardiac death after atrial switch repair surgery for D-transposition of the great arteries (D-TGA) are heterogeneous and limited by statistical power. Methods and Results We conducted a systematic review and meta-analysis of 29 observational studies, comprising 5035 patients, that reported mortality after atrial switch repair with a minimum follow-up of 10 years. We also examined 4 additional studies comprising 105 patients who reported rates of implantable cardioverter-defibrillator therapy in this population. Average survival dropped to 65% at 40 years after atrial switch repair, with sudden cardiac death accounting for 45% of all reported deaths. Mortality was significantly lower in cohorts that were more recent and operated on younger patients. Patient-level risk factors for late mortality were history of supraventricular tachycardia (odds ratio [OR] 3.8, 95% CI 1.4-10.7), Mustard procedure compared with Senning (OR 2.9, 95% CI 1.9-4.5) and complex D-TGA compared with simple D-TGA (OR 4.4, 95% CI 2.2-8.8). Significant risk factors for sudden cardiac death were history of supraventricular tachycardia (OR 4.7, 95% CI 2.2-9.8), Mustard procedure (OR 2.2, 95% CI 1.1-4.1), and complex D-TGA (OR 5.7, 95% CI 1.8-18.0). Out of a total 124 implantable cardioverter-defibrillator discharges over 330 patient-years in patients with implantable cardioverter-defibrillators for primary prevention, only 8% were appropriate. Conclusions Patient-level risk of both mortality and sudden cardiac death after atrial switch repair are significantly increased by history of supraventricular tachycardia, Mustard procedure, and complex D-TGA. This knowledge may help refine current selection practices for primary prevention implantable cardioverter-defibrillator implantation, given disproportionately high rates of inappropriate discharges.
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