Evidence map›Paper›PMID 31642183›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2019

Focused Ultrasound Preconditioning for Augmented Nanoparticle Penetration and Efficacy in the Central Nervous System.

Brian P Mead, Colleen T Curley, Namho Kim, Karina Negron, William J Garrison, Ji Song, Divya Rao, G Wilson Miller, James W Mandell, Benjamin W Purow and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  4. Review
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  6. Nanotherapeutics for Alleviating Anesthesia-Associated Complications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Brian P MeadDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Colleen T CurleyDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Namho KimCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Karina NegronCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
William J GarrisonDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Ji SongDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
Divya RaoCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
G Wilson MillerDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.
James W MandellDepartment of Pathology, University of Virginia, Charlottesville, VA, 22908, USA.
Benjamin W PurowDepartment of Neurology, University of Virginia, Charlottesville, VA, 22908, USA.
Jung Soo SukCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Justin HanesCenter for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD, 21231, USA.
Richard J PriceDepartment of Biomedical Engineering, University of Virginia, Charlottesville, VA, 22908, USA.ORCID 0000-0002-0237-2102
University of Virginia · USJohns Hopkins University · USUniversity of Virginia Medical Center · US

Funding

BASIC CARDIOVASCULAR RESEARCH TRAINING GRANTT32HL007284 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Brant E Isakson, Gary K Owens · 1985 to 2026
$19.6M
Cancer Research Training Program: From Molecular Mechanisms to Therapeutic StrategiesT32CA009109 · NCI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Andrew Carl Dudley, Melanie R Rutkowski · 1985 to 2026
$13.9M
Brain Tumor-Penetrating Nanoparticle Delivery with MR-Guided Focused UltrasoundR01CA164789 · NCI · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2012 to 2016
$3.1M
Immunotherapeutic Nanoparticle Delivery to Melanoma With MR-Guided Focused UltrasoundR01CA197111 · NCI · UNIVERSITY OF VIRGINIA · PI BULLOCK, TIMOTHY N, ENGELHARD, VICTOR H · 2015 to 2019
$2.6M
Innovative systemic gene therapy for treating Parkinson's diseaseR01NS111102 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI PRICE, RICHARD J., SUK, JUNG SOO · 2019 to 2023
$2.6M
Targeted Delivery of Brain Penetrating DNA Nanoparticles to Brain TumorsR01CA204968 · NCI · JOHNS HOPKINS UNIVERSITY · PI HANES, JUSTIN S., SUK, JUNG SOO · 2016 to 2020
$2.5M
MRI-Guided miRNA Nanoparticle Delivery to Glioblastoma With Focused UltrasoundR01EB020147 · NIBIB · UNIVERSITY OF VIRGINIA · PI HANES, JUSTIN S., PRICE, RICHARD J. · 2015 to 2018
$2.4M
Neurotrophic Nanoparticle Delivery with MRI-Guided Focused UltrasoundF31EB023090 · NIBIB · UNIVERSITY OF VIRGINIA · PI MEAD, BRIAN PATRICK · 2017 to 2017
$28k
NCI NIH HHS R01 CA164789NCI NIH HHS R01 CA197111NCI NIH HHS R01 CA204968NCI NIH HHS T32 CA009109NHLBI NIH HHS T32 HL007284NIBIB NIH HHS F31 EB023090NIBIB NIH HHS R01 EB020147NINDS NIH HHS R01 NS111102
6 · The paper itself

Abstract

Microbubble activation with focused ultrasound (FUS) facilitates the noninvasive and spatially-targeted delivery of systemically administered therapeutics across the blood-brain barrier (BBB). FUS also augments the penetration of nanoscale therapeutics through brain tissue; however, this secondary effect has not been leveraged. Here, 1 MHz FUS sequences that increase the volume of transfected brain tissue after convection-enhanced delivery of gene-vector "brain-penetrating" nanoparticles were first identified. Next, FUS preconditioning is applied prior to trans-BBB nanoparticle delivery, yielding up to a fivefold increase in subsequent transgene expression. Magnetic resonance imaging (MRI) analyses of tissue temperature and K

Indexed as

Ultrasonic WavesAnimalsBlood-Brain BarrierCentral Nervous SystemDrug Delivery SystemsMagnetic Resonance ImagingMicrobubblesNanoparticlesTemperaturefocused ultrasoundmicrobubblesnanoparticlesnonviral gene delivery

Identifiers

PMID31642183
PMCPMC7084172
OpenAlexW2981432669

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.