Evidence map›Paper›PMID 31642163›Full record

ArticleAngewandte Chemie (International ed. in English)2020

A Nanoscale Metal-Organic Framework to Mediate Photodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Enhance Antigen Presentation and Cancer Immunotherapy.

Kaiyuan Ni, Taokun Luo, Guangxu Lan, August Culbert, Yang Song, Tong Wu, Xiaomin Jiang, Wenbin Lin

Erratum issuedAbstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Targeted Drug Nanodelivery and Immunotherapy for Combating Tumor Resistance.Combinatorial chemistry & high throughput screening · 2025
    Review
  6. NIR-II light-drivenTheranostics · 2025
    Article
  7. Review
  8. Nanotechnology Applications in Breast Cancer Immunotherapy.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Biomaterials Facilitating Dendritic Cell-Mediated Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  18. Article
  19. Review
  20. Hybrid Nanomaterials for Cancer Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Kaiyuan NiDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Taokun LuoDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Guangxu LanDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
August CulbertDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Yang SongDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Tong WuDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Xiaomin JiangDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.
Wenbin LinDepartment of Chemistry, The University of Chicago, 929 East 57th street, Chicago, Illinois, 60637, USA.ORCID 0000-0001-7035-7759

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI MARK W. LINGEN · 1985 to 2026
$122.1M
Nanoscale Metal-organic Frameworks for Light Triggered and X-ray Induced Photodynamic Therapy of Head and Neck CancersU01CA198989 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2015 to 2019
$3.0M
Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersR01CA253655 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2020 to 2024
$2.5M
Nanoscale Metal-organic Frameworks for Imaging and Therapy of Pancreatic CancerU01CA151455 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LIN, WENBIN, YEH, JEN JEN · 2010 to 2014
$2.1M
Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian CancerR01CA216436 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN · 2018 to 2022
$2.1M
NCI NIH HHS 1R01CA216436NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA216436NCI NIH HHS R01 CA253655NCI NIH HHS U01 CA151455NCI NIH HHS U01 CA198989
6 · The paper itself

Abstract

Checkpoint blockade immunotherapy (CBI) awakes a host innate immune system and reactivates cytotoxic T cells to elicit durable response in some cancer patients. Now, a cationic nanoscale metal-organic framework, W-TBP, is used to facilitate tumor antigen presentation by enabling immunogenic photodynamic therapy (PDT) and promoting the maturation of dendritic cells (DCs). Comprised of dinuclear W

Indexed as

Antigen PresentationHumansImmunotherapyMetal-Organic FrameworksOligodeoxyribonucleotidesPhotochemotherapyMetal-Organic FrameworksOligodeoxyribonucleotidesantigen presentationcheckpoint blockade immunotherapyCpG deliverymetal-organic frameworksphotodynamic therapy

Identifiers

PMID31642163
PMCPMC8253508

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.