ArticleThe New phytologist2020
Convergent evolution of the UbiA prenyltransferase family underlies the independent acquisition of furanocoumarins in plants.
Article in The New phytologist, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 53 citations in OpenAlex.
- An aromatic substrate prenyltransferase involved in the chemical diversification of flavonoids in Glycyrrhiza glabra.Planta · 2026Article
- From Chemical Scaffold to Predicted Toxicity: A Scaffold-Aware Pipeline for Reliable In Silico Prioritization ofInternational journal of molecular sciences · 2026Article
- Bergapten as a Multifunctional Phytochemical in Cancer Therapy: Mechanistic Insights, Pharmacokinetics, and Possible Nanotechnology-Enabled Formulation Strategies.Pharmaceutics · 2026Review
- Elucidating the Furanocoumarin Biosynthetic Pathway inPlants (Basel, Switzerland) · 2026Article
- Coumarin metabolites in Ocimum: chemical diversity, biosynthetic pathways, and network pharmacology-based prediction of multi-target anticancer potential.Plant molecular biology · 2026Article
- Integrated Metabolome and Transcriptome Analysis in Ammi majus L. Revealed Candidate Genes of Furanocoumarins Pathway.Biochemical genetics · 2026Article
- Genome mining reveals the unique function of UbiA-type prenyltransferase in Laetiporus sulphureus.Natural products and bioprospecting · 2026Article
- Chitinase-activity-independent anti-insect effect of class V chitinase from fig trees (Ficus carica).Planta · 2025Article
- Flavonoids and Furanocoumarins Involved in Drug Interactions.Molecules (Basel, Switzerland) · 2025Review
- Catalytic mechanism underlying the regiospecificity of coumarin-substrate transmembrane prenyltransferases in Apiaceae.Plant & cell physiology · 2025Article
- The chromosome-scale assembly of theActa pharmaceutica Sinica. B · 2024Article
- Enzyme promiscuity powers plant chemical diversity: A case of prenyltransferases in biosynthesis of quinone derivatives.Plant physiology · 2024Article
- Molecular Cloning and Functional Identification of a Pericarp- and Testa-Abundant Gene's (International journal of molecular sciences · 2024Article
- Functions, accumulation, and biosynthesis of important secondary metabolites in the fig tree (Frontiers in plant science · 2024Review
- Bioengineering of the Marine DiatomInternational journal of molecular sciences · 2023Article
- Genome sequencing-based transcriptomic analysis reveals novel genes in Peucedanum praeruptorum.BMC genomic data · 2023Article
- Challenges in the Heterologous Production of Furanocoumarins inMolecules (Basel, Switzerland) · 2022Article
- Article
- Comparative Transcriptomics Unveil the Crucial Genes Involved in Coumarin Biosynthesis inFrontiers in plant science · 2022Article
- Parallel evolution of UbiA superfamily proteins into aromaticProceedings of the National Academy of Sciences of the United States of America · 2021Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Furanocoumarins (FCs) are plant-specialized metabolites with potent allelochemical properties. The distribution of FCs is scattered with a chemotaxonomical tendency towards four distant families with highly similar FC pathways. The mechanism by which this pathway emerged and spread in plants has not been elucidated. Furanocoumarin biosynthesis was investigated in Ficus carica (fig, Moraceae), focusing on the first committed reaction catalysed by an umbelliferone dimethylallyltransferase (UDT). Comparative RNA-seq analysis among latexes of different fig organs led to the identification of a UDT. The phylogenetic relationship of this UDT to previously reported Apiaceae UDTs was evaluated. The expression pattern of F. carica prenyltransferase 1 (FcPT1) was related to the FC contents in different latexes. Enzymatic characterization demonstrated that one of the main functions of FcPT1 is UDT activity. Phylogenetic analysis suggested that FcPT1 and Apiaceae UDTs are derived from distinct ancestors, although they both belong to the UbiA superfamily. These findings are supported by significant differences in the related gene structures. This report describes the identification of FcPT1 involved in FC biosynthesis in fig and provides new insights into multiple origins of the FC pathway and, more broadly, into the adaptation of plants to their environments.
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