ArticleInternational urology and nephrology2019
Metabolic syndrome is a predictor of decreased renal function among community-dwelling middle-aged and elderly Japanese.
Article in International urology and nephrology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Role of Endourological Procedures (PCNL and URS) on Renal Function: a Systematic Review.Current urology reports · 2020Pooled it
- Early signs of nephropathy in adolescents with obesity.International journal of obesity (2005) · 2026Article
- Impact of obesity on renal function in elderly Korean adults: a national population-based cohort study.Kidney research and clinical practice · 2026Article
- Morin Alleviates Fructose-Driven Disturbance of Podocyte Mitochondrial Energy Metabolism by Inhibiting Adenosine 5'-Monophosphate Deaminase Activity to Improve Glomerular Injury.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Association Between Oxidative-Inflammation Biomarkers and Incident Chronic Kidney Disease in People with High Cardiovascular Risk: A Nested Case-Control Study.Antioxidants (Basel, Switzerland) · 2025Article
- Association between Metabolic Syndrome Score and Subclinical Atherosclerosis.Reviews in cardiovascular medicine · 2025Article
- Metabolic syndrome as a risk factor for the development of kidney dysfunction: a meta-analysis of observational cohort studies.Journal of diabetes and metabolic disorders · 2024Review
- Chronic kidney disease combined with metabolic syndrome is a non-negligible risk factor.Therapeutic advances in endocrinology and metabolism · 2024Review
- The Triglyceride-Glucose Index is Independently Associated with Chronic Kidney Disease in the Geriatric Population, Regardless of Obesity and Sex.Annals of geriatric medicine and research · 2023Article
- The Effect of Metabolic Syndrome and Its Individual Components on Renal Function: A Meta-Analysis.Journal of clinical medicine · 2023Review
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- Predictive Value of HbA1c and Metabolic Syndrome for Renal Outcome in Non-Diabetic CKD Stage 1-4 Patients.Biomedicines · 2022Article
- The Impact of Hepatitis C Virus, Metabolic Disturbance, and Unhealthy Behavior on Chronic Kidney Disease: A Secondary Cross-Sectional Analysis.International journal of environmental research and public health · 2022Article
- Prevalence and associations of metabolic syndrome in patients with alcohol use disorder.Scientific reports · 2022Article
- Metabolic Syndrome-Related Kidney Injury: A Review and Update.Frontiers in endocrinology · 2022Review
- Incidence and correlation of metabolic syndrome and kidney stones in a healthy screening population.Translational andrology and urology · 2021Article
- The prevalence and associated factors of metabolic syndrome in Chinese aging population.Scientific reports · 2020Article
- Trajectory Patterns of Metabolic Syndrome Severity Score and Risk of Chronic Kidney Diseases.Kidney diseases (Basel, Switzerland)Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMetabolic syndrome (MetS) is increasing worldwide with the continuous increase in obesity prevalence. Chronic kidney disease (CKD) is also a major public health problem, but there is controversy over whether baseline MetS is a predictor of decreased renal function among Japanese community-dwelling middle-aged and elderly Japanese.
methodsWe conducted a prospective cohort study designed as part of the Nomura study. We recruited a random sample of 410 men aged 68 ± 8 (mean ± standard deviation; range, 50-95) years and 549 women aged 69 ± 7 (50-84) years during their annual health examination in a single community. We examined the relationship between baseline MetS and renal dysfunction after a 3-year evaluation based on estimated glomerular filtration rate (eGFR
resultsOf the 959 participants, 413 (43.1%) had MetS at baseline. Annual eGFR decline rate was significantly greater in those with MetS than in those without MetS, and the annual eGFR decline rate of < - 1.2 mL/min/1.73 m
conclusionsLow HDL-C and elevated HbA1c levels correlated significantly with eGFR decline in a short period of 3 years. MetS also showed a significant association with eGFR decline. This study suggests the importance of low HDL-C and elevated HbA1c in the effect of MetS on eGFR decline rather than obesity among Japanese community-dwelling middle-aged and elderly Japanese without CKD.
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