Evidence map›Paper›PMID 31641982›Full record

ReviewObesity surgery2019

Updates on Monogenic Obesity in a Multifactorial Disease.

Jared Baxter, Priscila Rodrigues Armijo, Laura Flores, Crystal Krause, Sarah Samreen, Tiffany Tanner

Abstract readReview
PubMed Publisher
In one paragraph

Review in Obesity surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jared BaxterCollege of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Priscila Rodrigues ArmijoCenter for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, USA.
Laura FloresCollege of Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Crystal KrauseCenter for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, USA.
Sarah SamreenCenter for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, USA.
Tiffany TannerCenter for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, USA. ttanner@unmc.edu.ORCID http://orcid.org/0000-0001-7801-1234
University of Nebraska Medical Center · USNebraska Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is a worldwide epidemic with rates nearly doubling over the last 30 years. Despite increasing prevalence, the multifactorial pathogenesis of obesity continues to be widely misunderstood. Investigating genetic drivers in the development of obesity is an important area of focus, as genetics move to the forefront of medicine and personalized treatment evolves. Thus, this narrative review focused on four genes which have genome-wide association study-documented links to obesity and obesity syndromes. We explored their involvement in the predisposition, progression, and prognosis of obesity. Leptin, leptin receptor, pro-opiomelanocortin, and melanocortin 4 receptor are our four genes of interest, and herein we elaborated on the current literature, pathogenesis, and available treatments for patients with these specific genetic mutations.

Indexed as

Disease ProgressionGenetic Predisposition to DiseaseGenome-Wide Association StudyGenotypeHumansLeptinMutationObesityPro-OpiomelanocortinReceptor, Melanocortin, Type 4Receptors, LeptinLeptinPro-OpiomelanocortinReceptor, Melanocortin, Type 4Receptors, LeptinGene mutationsGeneticsMonogenic obesityObesity

Identifiers

PMID31641982
OpenAlexW2982144219

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.