Evidence map›Paper›PMID 31641921›Full record

ArticleTransgenic research2020

Tamoxifen-independent recombination of reporter genes limits lineage tracing and mosaic analysis using CreER

A Álvarez-Aznar, I Martínez-Corral, N Daubel, C Betsholtz, T Mäkinen, K Gaengel

Open access · hybridAbstract read
In one paragraph

Article in Transgenic research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 99 citations in OpenAlex.

  1. ICER-Controlled inhibitory plasticity of amygdala engram neurons regulates fear memory precision.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. A new conditional mouse model for Cre-mediated restoration ofbioRxiv : the preprint server for biology · 2026
    Article
  3. Review
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  11. New knock-in mouse linesJBMR plus · 2026
    Article
  12. Review
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

A Álvarez-AznarDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden.
I Martínez-CorralDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden.
N DaubelDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden.
C BetsholtzDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden.
T MäkinenDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden.
K GaengelDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Dag Hammarskjöldsväg 20, 75185, Uppsala, Sweden. konstantin.gaengel@igp.uu.se.ORCID 0000-0002-2682-2833
Uppsala University · SE

Funding

Cancerfonden CAN2015/771Fondation Leducq (FR) 14-CVD-02H2020 European Research Council 2011-294556H2020 European Research Council ERC-2014-CoG-646849Knut och Alice Wallenbergs Stiftelse 2015.0030Knut och Alice Wallenbergs Stiftelse (SE) 2012.0272Vetenskapsrådet 542-2014-3535Vetenskapsrådet VR2015-00550
6 · The paper itself

Abstract

The CreER

Indexed as

Cell LineageGenes, ReporterRecombination, GeneticAnimalsBrainCell TrackingEstrogen AntagonistsFemaleIntegrasesMaleMiceMice, TransgenicReceptors, EstrogenRetinaTamoxifenCre recombinaseEstrogen AntagonistsIntegrasesReceptors, EstrogenTamoxifenCreERT2Cre/loxP systemLineage tracingMosaic analysisReporter-geneTamoxifen-independent recombination

Identifiers

PMID31641921
PMCPMC7000517
OpenAlexW2981497325

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.