ReviewThe ultrasound journal2019
Diagnostic value of transcranial ultrasonography for selecting subjects with large vessel occlusion: a systematic review.
Review in The ultrasound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- Drivers of bias in diagnostic test accuracy estimates when using expert panels as a reference standard: a simulation study.BMC medical research methodology · 2025Article
- Portable cerebral blood flow monitor to detect large vessel occlusion in patients with suspected stroke.Journal of neurointerventional surgery · 2025Observational
- Pre-Hospital Stroke Triage and Research: Challenges and Opportunities.Cerebrovascular diseases (Basel, Switzerland) · 2025Article
- A retrospective study of the Dual-channels Bolus Contrast Injection (Dc-BCI) technique during endovascular mechanical thrombectomy in the management of acute ischemic stroke due to large-vessel occlusion: a technical report.Frontiers in neurology · 2025Article
- Potential of transcranial ultrasound- and near-infrared spectroscopy-based acute stroke imaging for decision-making on intravenous thrombolysis treatment.Frontiers in neurology · 2025Article
- A Multi-Parametric Approach for Characterising Cerebral Haemodynamics in Acute Ischaemic and Haemorrhagic Stroke.Healthcare (Basel, Switzerland) · 2024Article
- Perioperative stroke during carotid endarterectomy: benefits of multimodal neuromonitoring - a case report.BMC neurology · 2022Article
- Large Vessel Occlusion Stroke Detection in the Prehospital Environment.Current emergency and hospital medicine reports · 2021Article
- Adapting pre-hospital stroke triage systems to expanding thrombectomy indications.Neuroradiology · 2021Article
- Article
- Transcranial Ultrasound in the Helicopter Emergency Medical Services-A Feasibility Study.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionA number of pre-hospital clinical assessment tools have been developed to triage subjects with acute stroke due to large vessel occlusion (LVO) to a specialised endovascular centre, but their false negative rates remain high leading to inappropriate and costly emergency transfers. Transcranial ultrasonography may represent a valuable pre-hospital tool for selecting patients with LVO who could benefit from rapid transfer to a dedicated centre.
methodsDiagnostic accuracy of transcranial ultrasonography in acute stroke was subjected to systematic review. Medline, Embase, PubMed, Scopus, and The Cochrane Library were searched. Published articles reporting diagnostic accuracy of transcranial ultrasonography in comparison to a reference imaging method were selected. Studies reporting estimates of diagnostic accuracy were included in the meta-analysis.
resultsTwenty-seven published articles were selected for the systematic review. Transcranial Doppler findings, such as absent or diminished blood flow signal in a major cerebral artery and asymmetry index ≥ 21% were shown to be suggestive of LVO. It demonstrated sensitivity ranging from 68 to 100% and specificity of 78-99% for detecting acute steno-occlusive lesions. Area under the receiver operating characteristics curve was 0.91. Transcranial ultrasonography can also detect haemorrhagic foci, however, its application is largely restricted by lesion location.
conclusionsTranscranial ultrasonography might potentially be used for the selection of subjects with acute LVO, to help streamline patient care and allow direct transfer to specialised endovascular centres. It can also assist in detecting haemorrhagic lesions in some cases, however, its applicability here is largely restricted. Additional research should optimize the scanning technique. Further work is required to demonstrate whether this diagnostic approach, possibly combined with clinical assessment, could be used at the pre-hospital stage to justify direct transfer to a regional thrombectomy centre in suitable cases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.