Evidence map›Paper›PMID 31641857›Full record

ArticleMolecular genetics and genomics : MGG2020

Phylogenetic relationship and genetic history of Central Asian Kazakhs inferred from Y-chromosome and autosomal variations.

Atif Adnan, Guanglin He, Allah Rakha, Kaidirina Kasimu, Jianxin Guo, Sibt E Hassan, Sibte Hadi, Chuan-Chao Wang, Jin-Feng Xuan

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In one paragraph

Article in Molecular genetics and genomics : MGG, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Atif Adnan *Department of Human Anatomy, School of Basic Medicine, China Medical University, Shenyang, 110122, China. mirzaatifadnan@gmail.com.
Guanglin He *Department of Anthropology and Ethnology, Institute of Anthropology, National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361005, China.
Allah RakhaDepartment of Forensic Sciences, University of Health Sciences, Lahore, 54000, Pakistan.
Kaidirina KasimuDepartment of Human Anatomy, School of Basic Medicine, China Medical University, Shenyang, 110122, China.
Jianxin GuoDepartment of Anthropology and Ethnology, Institute of Anthropology, National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361005, China.
Sibt E HassanDepartment of Human Anatomy, School of Basic Medicine, China Medical University, Shenyang, 110122, China.
Sibte HadiSchool of Forensic and Investigative Sciences, University of Central Lancashire, Preston, UK.
Chuan-Chao WangDepartment of Anthropology and Ethnology, Institute of Anthropology, National Institute for Data Science in Health and Medicine, Xiamen University, Xiamen, 361005, China. wang@xmu.edu.cn.
Jin-Feng XuanDepartment of Forensic Genetics and Biology, School of Forensic Medicine, China Medical University, Shenyang, 110122, China. jfxuan@cmu.edu.cn.
China Medical University · CNXiamen University · CNUniversity of Central Lancashire · GBUniversity of Health Sciences Lahore · PKWest China Medical Center of Sichuan University · CN

Funding

National Natural Science Foundation of China 31801040
6 · The paper itself

Abstract

The Xinjiang Uyghur Autonomous Region of China (XUARC) with 47 ethnic groups is a very colorful ethnic region of China, harboring abundant genetic and cultural diversity. The Kazakhs are the third largest ethnic group (7.02%) after Uyghur (46.42%) and Han (38.99%) in Xinjiang, but their genetic diversity and forensic characterization are poorly understood. In the current study, we genotyped 15 autosomal short tandem repeat (STR) loci and ten Y-STRs in 889 individuals (659 male and 230 female) collected from Kazak population of the Ili Kazak Autonomous Prefecture using AGCU Expressmarker 16 and 10Y-STR Kit (EX16 + 10Y). For autosomal STRs, we observed a total of 174 different alleles ranging from 6 to 34.2 repeat units and FGA showed the greatest power of discrimination (20 alleles) in Ili Kazakh population. We have not observed departures from Hardy-Weinberg equilibrium (HWE) after sequential Bonferroni correction and only found a minimal departure from linkage equilibrium (LE) for a very small number of pairwise combinations of loci. The combined power of exclusion (CPE) was 0.99999998395 and combined power of discrimination (CPD) was 99.999999999999999798%. For Y-STRs, we observed a total of 496 different haplotypes in these ten Y-STR loci. The gene diversities ranged from 0.5023 (DYS391) to 0.8357 (DYS385a/b). The overall haplotype diversity (GD) was 0.9985 with random matching probability (RMP) of 0.0015. The results of population genetic analysis based on both autosomal and Y-chromosome STRs demonstrated that the genetic affinity among populations is generally consistent with ethnic, linguistic, and continental geographical classifications.

Indexed as

AllelesAsian PeopleChromosomesFemaleGene FrequencyGenetics, PopulationGenetic TestingHaplotypesHumansMaleMicrosatellite RepeatsPhylogenyPolymorphism, GeneticExpressmarker 16 + 10Y STR KitForensic geneticsKazakhXinjiang Uyghur Autonomous Region

Identifiers

PMID31641857
OpenAlexW2981770655

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.